DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp2x10.2

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001315444.1	Gene:	cyp2x10.2 / 322545	ZFINID:	ZDB-GENE-060818-12	Length:	496	Species:	Danio rerio

Alignment Length:	509	Identity:	158/509 - (31%)
Similarity:	255/509 - (50%)	Gaps:	32/509 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTR-FMELAKQYGSLFST 90
            ::..|.||.|...|.:|....|..:..||||..:|:.|.||.:......: |.:.|:.|||::..
Zfish     1 MLTALVLLCLGAFLLYLQLRIRRPKNFPPGPAPVPIFGNLLQLNRISPLKDFDKFAQHYGSIYGI 65

  Fly    91 RLGSQLTVVMSDYKMIRECF--RREEFTGRPDT-PFMQTLNGYGIINST-GKLWKDQRRFLHDKL 151
            .:|||..||::..|||:|..  :..||:||.:. .|.....|.|:|.:. |:.|::.|||....|
Zfish    66 YIGSQPAVVLTGQKMIKEALITQAAEFSGRSNNMMFSHVTGGKGVIMADYGESWREHRRFALTTL 130

  Fly   152 RQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDD 216
            |.||:     ||:.|::||:.||......|..|.|:.:|...:...|.||:|.|::..:||:..|
Zfish   131 RNFGL-----GKKSMEQRILEEVKHICLLLEESAGKSIDPQHLYHQAASNIIASVIFGSRFNYKD 190

  Fly   217 PKFRRFNFLIEEGMRLFGEIHTV-------DYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVID 274
            ..|:.....:|:..::     |:       :..|.::.||   ....|..|...::.:....|::
Zfish   191 AYFQTLITSVEDLTKI-----TIGPWAMLYEIAPVLRIFP---LPFQKAFQYFEQITKHVLKVVE 247

  Fly   275 DHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLW 339
            :||.|......|||:|.||.|:|......|.   ||    |.|:|.::.|||.||.||...||..
Zfish   248 EHKTSRVAGEPRDLIDCYLEEMENKSDHRTS---FD----ESQMVTLLFDLFIAGTETTSNTLRT 305

  Fly   340 INVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRD 404
            :.::::.......:.|.|:|:|:|.....|.||...:...::.|.|..|.:.|.||:..||...|
Zfish   306 LTLYLMTYTHIQEQCQREIDEVLGARDHVTYEDRNAMHFVQAVIHEGQRVADIAPLSMFHSAKTD 370

  Fly   405 VELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGD 469
            .:|.||:||.|:.:||.::|...:...|:.|.||.|..|::.:|:..|.:.|:||..|.|:|||:
Zfish   371 TQLRGYSIPKGTIIIPYLSSSLREEGQWKFPHEFNPQNFLNEKGEFVKNDAFMPFSAGPRVCLGE 435

  Fly   470 VLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRRPLG 523
            .||||||||...:.:..|.:..|:....|......|.|.:.:.::|.::.|..|
Zfish   436 NLARMELFLILVTVLRRFRLVWPKDAGEPDFTYIYGGTQSVKPYRVIVEPRMHG 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	149/474 (31%)
cyp2x10.2	NP_001315444.1	p450	28..483	CDD:278495	149/474 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24427
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.720