DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2j3

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_786942.1	Gene:	Cyp2j3 / 313375	RGDID:	631442	Length:	502	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	163/505 - (32%)
Similarity:	262/505 - (51%)	Gaps:	37/505 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 HLLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMG-SEKHTRFMELAKQYGSLF 88
            ||.::.|..:..:.|..:|  .:|..:..|||||.||::|.|..:. .:.|....:..|:||::.
  Rat    17 HLRILLLAAVTFLFLADFL--KHRRPKNYPPGPWRLPLVGCLFHLDPKQPHLSLQQFVKKYGNVL 79

  Fly    89 STRLGSQLTVVMSDYKMIRECFRREE--FTGRPDTPFMQTL-NGYGIINSTGKLWKDQRRFLHDK 150
            |....:..:||::...:|:|.|.:.|  |..||.|...:.| |..|:|.|:|:.||:||||....
  Rat    80 SLDFANIPSVVVTGMPLIKEIFTQMEHNFLNRPVTLLRKHLFNKNGLIFSSGQTWKEQRRFALMT 144

  Fly   151 LRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSID 215
            ||.||:     ||:.:::||..|.:..:..:....|.|.|....|:.||||:|||:....||...
  Rat   145 LRNFGL-----GKKSLEQRIQEEAYHLVEAIKDEGGLPFDPHFNINKAVSNIICSVTFGERFEYH 204

  Fly   216 DPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQC-----FPSI----STAKNKIAQNRAEMQRFYQD 271
            |.:|:....|::|.|.|..         :|.|     ||.|    ..:...:..|..:::.|..|
  Rat   205 DSQFQEMLRLLDEAMCLES---------SMMCQLYNIFPRILQYLPGSHQTLFSNWRKLKLFISD 260

  Fly   272 VIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTT 336
            :|.:|:|.:||:..||.:|.:|.|:.|...:.|.:      .:||.|:...:|||.||.||..||
  Rat   261 IIKNHRRDWDPDEPRDFIDAFLKEMAKYPDKTTTS------FNEENLICSTLDLFFAGTETTSTT 319

  Fly   337 LLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSP 401
            |.|..:.|...|:...::|.|:|:|:|:.|.|.:.|...:|.|.:.|.|..|..:|:|.......
  Rat   320 LRWALLCMALYPEVQEKMQAEIDRVIGQGRQPNLADRDSMPYTNAVIHEVQRIGNIIPFNVPREV 384

  Fly   402 TRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMC 466
            ..|..|.|:.:|.|:.::..:.::|.||..|..|:.|.|..|:: .|:.:|.|.|:||.:|:|.|
  Rat   385 AVDTYLAGFNLPKGTMILTNLTALHRDPKEWATPDTFNPEHFLE-NGQFKKRESFLPFSMGKRAC 448

  Fly   467 LGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVC 516
            ||:.|||.|||:|..|.:..|....|..:.| ||:..:..||:|.|.::|
  Rat   449 LGEQLARSELFIFITSLIQKFTFKPPVNEKL-SLQFRMSVTISPVSHRLC 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	157/476 (33%)
Cyp2j3	NP_786942.1	p450	44..497	CDD:278495	156/474 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm45879
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820