DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp18a1 and Cyp2s1

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001100965.1	Gene:	Cyp2s1 / 308445	RGDID:	1306078	Length:	499	Species:	Rattus norvegicus

Alignment Length:	507	Identity:	168/507 - (33%)
Similarity:	272/507 - (53%)	Gaps:	43/507 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLL-FMGSEKHTRFMELAKQYGSLFS 89
            ||:..|.||..:||.:...|.     :|||||..||::|.|| ......::.|:.|:|:||.:|:
  Rat     9 LLLALLLLLLALTLPRTPARG-----QLPPGPTPLPLLGNLLQLRPGALYSGFLRLSKKYGPVFT 68

  Fly    90 TRLGS-QLTVVMSDYKMIRECF--RREEFTGRPDTPFM-QTLNGYGIINSTGKLWKDQRRFLHDK 150
            ..||. :..||:..:..|||..  :.|||:||.....: :|.:|:|:..:.|:.||..|:|....
  Rat    69 VHLGPWRRVVVLVGHDAIREALGGQAEEFSGRGTLATLDKTFDGHGVFFANGERWKQLRKFTLLA 133

  Fly   151 LRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSID 215
            ||..||     ||::.::.|..||...:.....::|:|.:.|.:::.|.|||:|||:...|...:
  Rat   134 LRDLGM-----GKREGEELIQEEVQNLVKAFQRTEGRPFNPSMLLAQATSNVVCSLIFGIRLPYE 193

  Fly   216 DPKFRRFNFLIE--EGMRL-----FGEIHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVI 273
            |   :.|..:|:  .|..|     :|:.:.: :...:|..|...|   ::..:...:..|....:
  Rat   194 D---KEFQAVIQAASGTLLGISSPWGQAYEM-FSWLLQPLPGPHT---QLQHHLGTLAAFTIQQV 251

  Fly   274 DDHK-RSFDPNNIRDLVDFYLCEIEKAKAE-GTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTT 336
            ..|: ||......||:||.:|.::.:.|.: ||:   |..||    |:..:..|..||..||..|
  Rat   252 QRHQGRSHTSGPARDVVDAFLQKMAQEKEDPGTE---FTEKN----LLMTVTYLLFAGTMTIGAT 309

  Fly   337 LLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSP 401
            :.:..:.:|:.|:..:||::||.|.:|..|.|::.|...||.|::.:.|:.|..::||:...|:.
  Rat   310 IRYALLLLLKYPQVQKRVREELIQELGPSRTPSLSDRVRLPYTDAVLHEAQRLLALVPMGMPHTV 374

  Fly   402 TRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMC 466
            |:.....|||:|.|:.|.|||.||..||.::..||||.||||:|.:|::||.|.|:|:.:|:|:|
  Rat   375 TKTTSFRGYTLPKGTEVFPLIGSVLHDPAVFRNPEEFHPSRFLDDDGRIRKHEAFLPYSLGKRVC 439

  Fly   467 LGDVLARMELFLFFASFMHCF--DIALPEGQPLPSLKGNV-GATITPESFKV 515
            ||:.|||.||:|||.|.:..|  |...|.|.  .|||..| |....|..|::
  Rat   440 LGEGLARAELWLFFTSILQAFSLDTPCPPGD--LSLKPAVRGLFNIPPDFQL 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	159/479 (33%)
Cyp2s1	NP_001100965.1	p450	48..491	CDD:365848	150/463 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010