Protein Alignment Cyp18a1 and Cyp4a3

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: XP_038965516.1
• Gene: Cyp4a3 / 298423
• RGDID: 631356
• Length: 511
• Species: Rattus norvegicus
• Alignment Length: 519
• Identity: 117/519 - (22%)
• Similarity: 203/519 - (39%)
• Gaps: 99/519 - (19%)

  Fly    26 LLMVFLGLLALVTLL---QWLVRNYRELRKLPPGP----WGLPVIGYLLFMGSEKHTRFME---- 79
            ||.:||.|...|...   |||:   :.|.|.|..|    ||..:          |...|.:
  Rat    24 LLSLFLVLFKAVQFYLRRQWLL---KALEKFPSTPSHWLWGHDL----------KDREFQQVLTW 75

  Fly    80 LAKQYGSLFSTRLGSQLTVVMSDYKMIRECFRREEFTGRPD----------TPFMQTLNGYGIIN 134
            :.|..|:......||:..|::.|...::...      ||.|          .|::.:..|||::.
  Rat    76 VEKFPGACLQWLSGSKTRVLLYDPDYVKVVL------GRSDPKASGIYQFLAPWIVSGTGYGLLL 134

  Fly   135 STGKLWKDQRRFLHDKLRQFGMTYMGNGKQQMQKRIMTE-VHEFIGHLHASDGQ--PVDMSPVIS 196
            ..||.|     |.|.::......|   |..:...:||.: |...:......|.|  |:::...:|
  Rat   135 LNGKKW-----FQHWRMLTPAFHY---GILKPYVKIMADSVSIMLDKWEKLDDQDHPLEIFHYVS 191

  Fly   197 VAVSNVICSLMMSTRFSID-DPKFRRFNFLIEEGMRL-FGEIHTVDY----IPTMQCFPSISTAK 255
            :...:.:.....|.:.|:. |...|.:...:|:...| |..:.:..|    |..|.....:|...
  Rat   192 LMTLDTVMKCAFSHQGSVQLDVNSRSYTKAVEDLNNLTFFRVRSAFYGNSIIYNMSSDGRLSRRA 256

  Fly   256 NKIA---------------QNRAEMQRFYQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTD 305
            .:||               ||..|:|:..:      ||..|   ..|::.|
  Rat   257 CQIAHEHTDGVIKMRKAQLQNEEELQKARK------KRHLD---FLDILLF-------------- 298

  Fly   306 AELFDGKNHEEQLVQVIIDLFS-AGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPT 369
            |::.|||:..::.::..:|.|. .|.:|..:.:.|:...:..:|:...|.::|:..::|.....|
  Rat   299 AKMEDGKSLSDEDLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSILGDGTSVT 363

  Fly   370 IEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEK 434
            .:.|..:..|...|.|::|....||..:....:.....:|.:||.|.....||..:|.:|:.|..
  Rat   364 WDHLDQISYTTMCIKEALRLYPPVPSVSRELSSPVTFPDGRSIPKGITTTILIYGLHHNPSYWPN 428

  Fly   435 PEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLP 498
            |:.|.||||  :....|....::||..|.|.|:|...|..||.:..|..:..|:: ||:...:|
  Rat   429 PKVFDPSRF--SPDSPRHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFEL-LPDPTRIP 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	99/449 (22%)
Cyp4a3	XP_038965516.1	CYP4B-like	69..506	CDD:410771	101/461 (22%)