Protein Alignment Cyp18a1 and CYP2S1

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_085125.1
• Gene: CYP2S1 / 29785
• HGNCID: 15654
• Length: 504
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 163/515 - (31%)
• Similarity: 266/515 - (51%)
• Gaps: 49/515 - (9%)

  Fly    27 LMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLL-FMGSEKHTRFMELAKQYGSLFST 90
            |::.|.||.|:||   .:...|....|||||..||::|.|| ......::..|.|:|:||.:|:.
Human     9 LLLALALLLLLTL---ALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPVFTI 70

  Fly    91 RLGS-QLTVVMSDYKMIRECF--RREEFTGRPDTPFMQ-TLNGYGIINSTGKLWKDQRRFLHDKL 151
            .||. :..||:...:.:||..  :.|||:||.....:: |.:|:|:..|.|:.|:..|:|....|
Human    71 YLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQLRKFTMLAL 135

  Fly   152 RQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDD 216
            |..||     ||::.::.|..|....:.....::|:|.|.|.:::.|.|||:|||:...|||.:|
Human   136 RDLGM-----GKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYED 195

  Fly   217 PKFRRFNFLIEEGMRLFGEI----HTVDYI---------PTMQCFPSISTAKNKIAQNRAEMQRF 268
            .:|:.  .:...|..|.|..    .|.:..         |..|....:||           :..|
Human   196 KEFQA--VVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVST-----------LAAF 247

  Fly   269 YQDVIDDHKRSFDPNN-IRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMET 332
            ....:..|:.:.|.:. .|||||.:|  ::.|:.|......|..||    ::..:|.|..||..|
Human   248 TVRQVQQHQGNLDASGPARDLVDAFL--LKMAQEEQNPGTEFTNKN----MLMTVIYLLFAGTMT 306

  Fly   333 IKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLAT 397
            :.||:.:..:.:::.|...:.|::||::.:|..:.|::.|...||.|::.:.|:.|..::||:..
Human   307 VSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGI 371

  Fly   398 THSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVG 462
            ..:..|.....|||:|.|:.|.||:.|:..|||:::.||||.|.||:|.:|:.||.|.|:||.:|
Human   372 PRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLG 436

  Fly   463 RRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNV-GATITPESFKVCLKRRP 521
            :|:|||:.||:.||||||.:.:..|.:..|......|||..| |....|.:|:  |:.||
Human   437 KRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAFQ--LQVRP 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	138/448 (31%)
CYP2S1	NP_085125.1	CYP2	64..490	CDD:410652	139/451 (31%)