DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2c6v1

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001013926.2	Gene:	Cyp2c6v1 / 293989	RGDID:	619934	Length:	490	Species:	Rattus norvegicus

Alignment Length:	484	Identity:	156/484 - (32%)
Similarity:	242/484 - (50%)	Gaps:	49/484 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTRFM-ELAKQYGSLFS 89
            ::::.|.|..|:.|..|  |......||||||..||:||.:..:..:..|:.: ..:|.||.:|:
  Rat     4 VMLLVLTLTCLILLSIW--RQSSGRGKLPPGPIPLPIIGNIFQLNVKNITQSLTSFSKVYGPVFT 66

  Fly    90 TRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTLN-GYGIINSTGKLWKDQRRFLHDKL 151
            ...|::.||::..|:.::|..  ..|||..|...|..:.:| ..||:.|.|..||:.|||....|
  Rat    67 LYFGTKPTVILHGYEAVKEALIDHGEEFAERGSFPVAEKINKDLGIVFSHGNRWKEIRRFTLTTL 131

  Fly   152 RQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDD 216
            |..||     ||:.::.|:..|....:..|..::|.|.|.:.::..|..|||||::...||...|
  Rat   132 RNLGM-----GKRNIEDRVQEEARCLVEELRKTNGSPCDPTFILGCAPCNVICSIIFQNRFDYKD 191

  Fly   217 PKFRRFNFLIEEGMRLFGEIHT---------VDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDV 272
            ..|......:.|.|::.....|         :||.|         .:...:|:|...::.:....
  Rat   192 QDFLNLMEKLNENMKILSSPWTQFCSFFPVLIDYCP---------GSHTTLAKNVYHIRNYLLKK 247

  Fly   273 IDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHE-------EQLVQVIIDLFSAGM 330
            |.:|:.|.|..|.||.:|:||.   |.|.|          ||.       |.|...:.|||.||.
  Rat   248 IKEHQESLDVTNPRDFIDYYLI---KWKQE----------NHNPHSEFTLENLSITVTDLFGAGT 299

  Fly   331 ETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPL 395
            ||..|||.:..:.:|:.|:...:||:|:|:|||:||.|.::|...:|.|::.|.|..|...::|.
  Rat   300 ETTSTTLRYALLLLLKCPEVTAKVQEEIDRVVGKHRSPCMQDRSRMPYTDAMIHEVQRFIDLIPT 364

  Fly   396 ATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFG 460
            ...|:.|.|::...|.||.|:.:|..::||..|...:..||.|.|..|:|..||.:|.:||:||.
  Rat   365 NLPHAVTCDIKFRNYLIPKGTTIITSLSSVLHDSKEFPDPEIFDPGHFLDGNGKFKKSDYFMPFS 429

  Fly   461 VGRRMCLGDVLARMELFLFFASFMHCFDI 489
            .|:|||.|:.|||||||||..:.:..|.:
  Rat   430 AGKRMCAGEGLARMELFLFLTTILQNFKL 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	148/456 (32%)
Cyp2c6v1	NP_001013926.2	CYP2C-like	61..485	CDD:410758	138/425 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820