DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2c7

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_058854.1	Gene:	Cyp2c7 / 29298	RGDID:	620379	Length:	490	Species:	Rattus norvegicus

Alignment Length:	507	Identity:	168/507 - (33%)
Similarity:	267/507 - (52%)	Gaps:	40/507 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LMVF--LGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMG----SEKHTRFMELAKQYG 85
            |:.|  |.|.:|:.|..|  |.....|||||||..||:||..|.:.    |:..|:|   :|.||
  Rat     3 LVTFLVLTLSSLILLSLW--RQSSRRRKLPPGPTPLPIIGNFLQIDVKNISQSLTKF---SKTYG 62

  Fly    86 SLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTL-NGYGIINSTGKLWKDQRRFL 147
            .:|:..||||.||::..|:.|:|..  ..|:|:||...|..:.: .|:||:.|.|..||:.|||.
  Rat    63 PVFTLYLGSQPTVILHGYEAIKEALIDNGEKFSGRGSYPMNENVTKGFGIVFSNGNRWKEMRRFT 127

  Fly   148 HDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRF 212
            ....|..|:     ||:.::.|:..|....:..|..:.|.|.|.|.:::.|..|||||:.....|
  Rat   128 IMNFRNLGI-----GKRNIEDRVQEEAQCLVEELRKTKGSPCDPSLILNCAPCNVICSITFQNHF 187

  Fly   213 SIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQ-C--FPSI----STAKNKIAQNRAEMQRFYQ 270
            ...|.:...|...:.|.:::...       |.|| |  |||:    ....:|||:|...|:.:..
  Rat   188 DYKDKEMLTFMEKVNENLKIMSS-------PWMQVCNSFPSLIDYFPGTHHKIAKNINYMKSYLL 245

  Fly   271 DVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKT 335
            ..|::|:.|.|..|.||.||:||  |::.:|...:...:.    .|.|...|:||..||.||:.|
  Rat   246 KKIEEHQESLDVTNPRDFVDYYL--IKQKQANNIEQSEYS----HENLTCSIMDLIGAGTETMST 304

  Fly   336 TLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHS 400
            ||.:..:.:::.|....:||:|:|:|:||||.|.::|.:::|.|::.|.|..|..:.||....|:
  Rat   305 TLRYALLLLMKYPHVTAKVQEEIDRVIGRHRSPCMQDRKHMPYTDAMIHEVQRFINFVPTNLPHA 369

  Fly   401 PTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRM 465
            .|.|::...|.||.|:.|:..:.||..|...:..||.|.|..|:|..|..:|.:||:||..|:|.
  Rat   370 VTCDIKFRNYLIPKGTKVLTSLTSVLHDSKEFPNPEMFDPGHFLDENGNFKKSDYFLPFSAGKRA 434

  Fly   466 CLGDVLARMELFLFFASFMHCFDI-ALPEGQPLPSLKGNVGATITPESFKVC 516
            |:|:.||||:||||..:.:..|:: :|...:.:.::....|....|.::::|
  Rat   435 CVGEGLARMQLFLFLTTILQNFNLKSLVHPKDIDTMPVLNGFASLPPTYQLC 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	157/478 (33%)
Cyp2c7	NP_058854.1	p450	30..487	CDD:278495	157/478 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920