Protein Alignment Cyp18a1 and Cyp2b12

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_058852.2
• Gene: Cyp2b12 / 29295
• RGDID: 620088
• Length: 492
• Species: Rattus norvegicus
• Alignment Length: 505
• Identity: 166/505 - (32%)
• Similarity: 258/505 - (51%)
• Gaps: 50/505 - (9%)

  Fly    32 GLLALVTL----LQWLVRNYRELR--KLPPGPWGLPVIGYLL------FMGSEKHTRFMELAKQY 84
            |:|.|:||    |.:||...:...  .|||||..||.:|.||      |:.|     ||:|.::|
  Rat     4 GVLLLLTLTVGFLLFLVSQSQPKTHGHLPPGPRPLPFLGNLLQMNRRGFLNS-----FMQLQEKY 63

  Fly    85 GSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQ-TLNGYGIINSTGKLWKDQRRF 146
            |.:|:..||.:..|::.....|||..  :.|.|:||.....:. .:.|||:|.:||:.||..|||
  Rat    64 GDVFTVHLGPRPVVILCGTDTIREALVDQAEAFSGRGTVAVLHPVVQGYGVIFATGERWKTLRRF 128

  Fly   147 LHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTR 211
            ....:::|||     ||:.:.:||..|....:..|....|.|::.:.:.....:|.|||::...|
  Rat   129 SLVTMKEFGM-----GKRSVDERIKEEAQCLVEELKKYKGAPLNPTFLFQSIAANTICSIVFGER 188

  Fly   212 FSIDDPKFRRFNFLIEEGMRLFGEIHTVD---YIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVI 273
            |...|.:|.....|:.:...|.|.:.:..   |...::.||.   |..:|.:|..||..:...::
  Rat   189 FDYKDHQFLHLLDLVYKTSVLMGSLSSQVFELYSGFLKYFPG---AHKQIFKNLQEMLNYIGHIV 250

  Fly   274 DDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNH-----EEQLVQVIIDLFSAGMETI 333
            :.|:.:.||:..||.:|.||..:||.|:           ||     .:.||..::.||.||.||.
  Rat   251 EKHRATLDPSAPRDFIDTYLLRMEKEKS-----------NHHTEFNHQNLVISVLSLFFAGTETT 304

  Fly   334 KTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATT 398
            .|||....:.||:.|....:||.|:|||:|.|||||.:|...:|.|::.|.|..|.:.:.|:...
  Rat   305 STTLRCTFLIMLKYPHVAEKVQKEIDQVIGSHRLPTPDDRTKMPYTDAVIHEIQRFADLTPIGLP 369

  Fly   399 HSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGR 463
            |..|:|....||.:|..:.|.|:::|...||..:|:|:.|.|..|:|..|.::|.|.|:||..|:
  Rat   370 HRVTKDTVFRGYLLPKNTEVYPILSSALHDPRYFEQPDTFNPEHFLDANGALKKSEAFLPFSTGK 434

  Fly   464 RMCLGDVLARMELFLFFASFMHCFDIA---LPEGQPLPSLKGNVGATITP 510
            |:|||:.:||.|||:||.:.:..|.:|   .||...|..:...||...:|
  Rat   435 RICLGEGIARNELFIFFTAILQNFTLASPVAPEDIDLTPINSGVGKIPSP 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	142/440 (32%)
Cyp2b12	NP_058852.2	CYP2B	63..487	CDD:410765	143/441 (32%)