Protein Alignment Cyp18a1 and Cyp2c11

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_062057.2
• Gene: Cyp2c11 / 29277
• RGDID: 2469
• Length: 500
• Species: Rattus norvegicus
• Alignment Length: 512
• Identity: 166/512 - (32%)
• Similarity: 266/512 - (51%)
• Gaps: 50/512 - (9%)

  Fly    26 LLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIG-----YLLFMGSEKHTRFMELAKQYG 85
            :|::.|.|.:|:.|..|  |......||||||..||:||     |:..:|..    ..:.:|.||
  Rat     4 VLVLVLTLSSLLLLSLW--RQSFGRGKLPPGPTPLPIIGNTLQIYMKDIGQS----IKKFSKVYG 62

  Fly    86 SLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTLN-GYGIINSTGKLWKDQRRFL 147
            .:|:..||.:..||:..|:.::|..  ..|||:||...|..:.:| |.|:|.|.|..||:.|||.
  Rat    63 PIFTLYLGMKPFVVLHGYEAVKEALVDLGEEFSGRGSFPVSERVNKGLGVIFSNGMQWKEIRRFS 127

  Fly   148 HDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRF 212
            ...||.|||     ||:.::.||..|....:..|..|.|.|.|.:.::..|..|||||::...||
  Rat   128 IMTLRTFGM-----GKRTIEDRIQEEAQCLVEELRKSKGAPFDPTFILGCAPCNVICSIIFQNRF 187

  Fly   213 SIDDPKF----RRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSI----STAKNKIAQNRAEMQRFY 269
            ...||.|    .|||    |..|||..    .::.....||:|    ..:.|::.:|...::.:.
  Rat   188 DYKDPTFLNLMHRFN----ENFRLFSS----PWLQVCNTFPAIIDYFPGSHNQVLKNFFYIKNYV 244

  Fly   270 QDVIDDHKRSFDPNNIRDLVDFYLCEIEKAK----AEGTDAELFDGKNHEEQLVQVIIDLFSAGM 330
            .:.:.:|:.|.|.:|.||.:|.:|.::|:.|    :|.|          .|.||..:.|:|.||.
  Rat   245 LEKVKEHQESLDKDNPRDFIDCFLNKMEQEKHNPQSEFT----------LESLVATVTDMFGAGT 299

  Fly   331 ETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPL 395
            ||..|||.:..:.:|::.....:||:|:::|:||:|.|.::|...:|.|::.:.|..|...:||.
  Rat   300 ETTSTTLRYGLLLLLKHVDVTAKVQEEIERVIGRNRSPCMKDRSQMPYTDAVVHEIQRYIDLVPT 364

  Fly   396 ATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFG 460
            ...|..|||::...|.||.|::||..::|:..|...:..||:|.|..|:|..|..:|.:||:||.
  Rat   365 NLPHLVTRDIKFRNYFIPKGTNVIVSLSSILHDDKEFPNPEKFDPGHFLDERGNFKKSDYFMPFS 429

  Fly   461 VGRRMCLGDVLARMELFLFFASFMHCFDI-ALPEGQPLPSLKGNVGATITPESFKVC 516
            .|:|:|.|:.|||.||||||.:.:..|:: :|.:.:.:.:.....|....|..::.|
  Rat   430 AGKRICAGEALARTELFLFFTTILQNFNLKSLVDVKDIDTTPAISGFGHLPPFYEAC 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	144/445 (32%)
Cyp2c11	NP_062057.2	CYP2C-like	61..484	CDD:410758	145/445 (33%)