DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2b21

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_942028.1	Gene:	Cyp2b21 / 292728	RGDID:	735174	Length:	494	Species:	Rattus norvegicus

Alignment Length:	507	Identity:	163/507 - (32%)
Similarity:	257/507 - (50%)	Gaps:	36/507 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LLALVT-LLQWLVRNY-RELRKLPPGPWGLPVIGYLLFMGSEKHTR-FMELAKQYGSLFSTRLGS 94
            |.||:| .|..|:|.. .....|||||..||::|.:|.|......: |::|..:||.:.:..||.
  Rat     8 LFALLTGFLLLLIRGQGNGYGHLPPGPCPLPLLGNVLQMDRRGLLKSFIQLRDKYGDVVTVHLGP 72

  Fly    95 QLTVVMSDYKMIRECF--RREEFTGRPDTPFMQ-TLNGYGIINSTGKLWKDQRRFLHDKLRQFGM 156
            :..|::...:.|||..  ..|.|:||.....:| .:..||:|.:.|:.||..|||....:|.|||
  Rat    73 RPIVMLYGTETIREALVDHAEAFSGRGTVAVVQPIIQDYGMIFANGERWKILRRFSLATMRDFGM 137

  Fly   157 TYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKFRR 221
                 ||:.:::||..|....:..|....|.|:|.:..:....:|:|||::...||...|.:|..
  Rat   138 -----GKRSVEERIKEEAQCLVEELKKYKGAPLDPTFHLQCITANIICSIVFGERFDYTDHQFLH 197

  Fly   222 FNFLIEEGMRLFG-------EIHT--VDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDHK 277
            ...|..|.:.|..       |:.|  :.|.|        .|.:: |::|..|:..|....::.|:
  Rat   198 LLDLFYEILSLVSSFSSQVFELFTGFLKYFP--------GTHRH-ISKNIEEILNFIGHCVEKHR 253

  Fly   278 RSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINV 342
            .:.||:..||.:|.||..:||.|..      ...:.|.:.|:..::.||.||.||..|||.:..:
  Rat   254 ATLDPSTPRDFIDTYLLRMEKEKLN------HHTEFHHQNLMMSVLSLFFAGTETSSTTLRYGFL 312

  Fly   343 FMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVEL 407
            .||:.|....:||.|:|||:|.||:||::|...:|.|::.|.|..|.|.:||:...|..|:|...
  Rat   313 LMLKYPHVAEKVQKEIDQVIGSHRVPTLDDRIKMPYTDAVIHEIQRFSDLVPIGLPHRVTKDTLF 377

  Fly   408 NGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLA 472
            .||.:|....|.|:::|...||..:|.|:.|.|..|:|..|.::|.|.|:||..|:|:|||:.:|
  Rat   378 RGYLLPKNIEVYPILSSALHDPQYFEHPDTFNPEHFLDANGALKKNEAFLPFSTGKRVCLGEGIA 442

  Fly   473 RMELFLFFASFMHCFDIALP-EGQPLPSLKGNVGATITPESFKVCLKRRPLG 523
            |.||||||.:.:..|.::.| ..:.:.......|....|.::::|...|.||
  Rat   443 RNELFLFFTTILQNFSVSSPVSPKDIDLTPKESGFAKIPPTYQICFLSRQLG 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	151/476 (32%)
Cyp2b21	NP_942028.1	p450	42..488	CDD:278495	144/465 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720