DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2b3

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_775416.1	Gene:	Cyp2b3 / 286953	RGDID:	628627	Length:	491	Species:	Rattus norvegicus

Alignment Length:	511	Identity:	154/511 - (30%)
Similarity:	253/511 - (49%)	Gaps:	43/511 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 VFLGLLALVTLLQWLVRNYRELR-KLPPGPWGLPVIGYLLFM---GSEKHTRFMELAKQYGSLFS 89
            |.|.|..|::.|.:|||.:.::. .|||||..||::|.||.|   |..|  .|::|.:::|.:|:
  Rat     5 VLLLLAVLLSFLLFLVRGHAKVHGHLPPGPRPLPLLGNLLQMDRGGFRK--SFIQLQEKHGDVFT 67

  Fly    90 TRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQ-TLNGYGIINSTGKLWKDQRRFLHDKL 151
            ...|.:..|::...:.|||..  ..|.|:||.....:| .:..||:.....:.||..||.....:
  Rat    68 VYFGPRPVVMLCGTQTIREALVDHAEAFSGRGIIAVLQPIMQEYGVSFVNEERWKILRRLFVATM 132

  Fly   152 RQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDD 216
            |.||:     |||.::.:|..|....:..|....|..:|.:.:......|:|||::...||...|
  Rat   133 RDFGI-----GKQSVEDQIKEEAKCLVEELKNHQGVSLDPTFLFQCVTGNIICSIVFGERFDYRD 192

  Fly   217 PKFRRFNFLIEEGMRLFGEIHTVD------YIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDD 275
            .:|.|   |::...|.|..|.:..      |...::.||.:   ..:|.:|..|:..:....:::
  Rat   193 RQFLR---LLDLLYRTFSLISSFSSQMFEVYSDFLKYFPGV---HREIYKNLKEVLDYIDHSVEN 251

  Fly   276 HKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQ-----LVQVIIDLFSAGMETIKT 335
            |:.:.|||..||.:|.:|..:||.|.           ||..:     |:..::.||.||.|:...
  Rat   252 HRATLDPNAPRDFIDTFLLHMEKEKL-----------NHYTEFHHWNLMISVLFLFLAGTESTSN 305

  Fly   336 TLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHS 400
            ||.:..:.||:.|....:||.|:|||:|..|:||::|...:|.||:.|.|..|.|.:.|:.....
  Rat   306 TLCYGFLLMLKYPHVAEKVQKEIDQVIGSQRVPTLDDRSKMPYTEAVIHEIQRFSDVSPMGLPCR 370

  Fly   401 PTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRM 465
            .|:|....||.:|..:.|..:::|...||..:|:|:.|.|..|:|..|.::|.|.|:||.:|:||
  Rat   371 ITKDTLFRGYLLPKNTEVYFILSSALHDPQYFEQPDTFNPEHFLDANGALKKCEAFMPFSIGKRM 435

  Fly   466 CLGDVLARMELFLFFASFMHCFDIALP-EGQPLPSLKGNVGATITPESFKVCLKRR 520
            |||:.:||.||||||.:.:..:.::.| :...:.......|.......:|:|...|
  Rat   436 CLGEGIARSELFLFFTTILQNYSVSSPVDPNTIDMTPKESGLAKVAPVYKICFVAR 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	143/480 (30%)
Cyp2b3	NP_775416.1	p450	42..488	CDD:278495	136/469 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720