DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2d1

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_695225.1	Gene:	Cyp2d1 / 266684	RGDID:	708427	Length:	504	Species:	Rattus norvegicus

Alignment Length:	504	Identity:	170/504 - (33%)
Similarity:	260/504 - (51%)	Gaps:	37/504 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 VTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMG-SEKHTRFMELAKQYGSLFSTRLGSQLTVVM 100
            :.|:..:.|.:|...:.||||...||:|.||.:. |.......:|..:||.:||.:.|.:..|::
  Rat    20 ILLVDLMHRRHRWTSRYPPGPVPWPVLGNLLQVDLSNMPYSLYKLQHRYGDVFSLQKGWKPMVIV 84

  Fly   101 SDYKMIRECF--RREEFTGRPDTPFMQTL----NGYGII-NSTGKLWKDQRRFLHDKLRQFGMTY 158
            :..|.::|..  ..|:...||..|..:.|    ...|:| .|.|..|::||||....||.|||
  Rat    85 NRLKAVQEVLVTHGEDTADRPPVPIFKCLGVKPRSQGVILASYGPEWREQRRFSVSTLRTFGM-- 147

  Fly   159 MGNGKQQMQKRIMTEVHEFIGHL----HASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKF 219
               ||:.:::.:..|.    |||    .|..||.::...:::.|:.|||.||:.:.||..:||..
  Rat   148 ---GKKSLEEWVTKEA----GHLCDAFTAQAGQSINPKAMLNKALCNVIASLIFARRFEYEDPYL 205

  Fly   220 RRFNFLIEEGMRLFGEIHTVDYIP-TMQCFPS---ISTAKNKIAQNRAEMQRFYQDVIDDHKRSF 280
            .|...|:||.:     .....:|| .:..||:   |....:|:.|.:........:::.:::.::
  Rat   206 IRMVKLVEESL-----TEVSGFIPEVLNTFPALLRIPGLADKVFQGQKTFMALLDNLLAENRTTW 265

  Fly   281 DP-NNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFM 344
            || ...|:|.|.:|.|:||||  |.....|    ::|.|..|::|||:|||.|..|||.|..:.|
  Rat   266 DPAQPPRNLTDAFLAEVEKAK--GNPESSF----NDENLRMVVVDLFTAGMVTTATTLTWALLLM 324

  Fly   345 LRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNG 409
            :..|...||||.|:|:|:|:.|.|.:.|..::|.|.:.|.|..|...|.||......:.|:|:..
  Rat   325 ILYPDVQRRVQQEIDEVIGQVRCPEMTDQAHMPYTNAVIHEVQRFGDIAPLNLPRITSCDIEVQD 389

  Fly   410 YTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLARM 474
            :.||.|:.:|..::||..|..:||||..|.|..|:|.:|...|.|.|:||..|||.|||:.||||
  Rat   390 FVIPKGTTLIINLSSVLKDETVWEKPHRFHPEHFLDAQGNFVKHEAFMPFSAGRRACLGEPLARM 454

  Fly   475 ELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRRPLG 523
            ||||||...:..|..::|.|||.||..|.....:.|..:::|...|..|
  Rat   455 ELFLFFTCLLQRFSFSVPVGQPRPSTHGFFAFPVAPLPYQLCAVVREQG 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	164/479 (34%)
Cyp2d1	NP_695225.1	p450	37..496	CDD:278495	164/478 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810