Protein Alignment Cyp18a1 and Cyp2d1

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_695225.1
• Gene: Cyp2d1 / 266684
• RGDID: 708427
• Length: 504
• Species: Rattus norvegicus
• Alignment Length: 504
• Identity: 170/504 - (33%)
• Similarity: 260/504 - (51%)
• Gaps: 37/504 - (7%)

  Fly    37 VTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMG-SEKHTRFMELAKQYGSLFSTRLGSQLTVVM 100
            :.|:..:.|.:|...:.||||...||:|.||.:. |.......:|..:||.:||.:.|.:..|::
  Rat    20 ILLVDLMHRRHRWTSRYPPGPVPWPVLGNLLQVDLSNMPYSLYKLQHRYGDVFSLQKGWKPMVIV 84

  Fly   101 SDYKMIRECF--RREEFTGRPDTPFMQTL----NGYGII-NSTGKLWKDQRRFLHDKLRQFGMTY 158
            :..|.::|..  ..|:...||..|..:.|    ...|:| .|.|..|::||||....||.|||
  Rat    85 NRLKAVQEVLVTHGEDTADRPPVPIFKCLGVKPRSQGVILASYGPEWREQRRFSVSTLRTFGM-- 147

  Fly   159 MGNGKQQMQKRIMTEVHEFIGHL----HASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKF 219
               ||:.:::.:..|.    |||    .|..||.::...:::.|:.|||.||:.:.||..:||..
  Rat   148 ---GKKSLEEWVTKEA----GHLCDAFTAQAGQSINPKAMLNKALCNVIASLIFARRFEYEDPYL 205

  Fly   220 RRFNFLIEEGMRLFGEIHTVDYIP-TMQCFPS---ISTAKNKIAQNRAEMQRFYQDVIDDHKRSF 280
            .|...|:||.:     .....:|| .:..||:   |....:|:.|.:........:::.:::.::
  Rat   206 IRMVKLVEESL-----TEVSGFIPEVLNTFPALLRIPGLADKVFQGQKTFMALLDNLLAENRTTW 265

  Fly   281 DP-NNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFM 344
            || ...|:|.|.:|.|:||||  |.....|    ::|.|..|::|||:|||.|..|||.|..:.|
  Rat   266 DPAQPPRNLTDAFLAEVEKAK--GNPESSF----NDENLRMVVVDLFTAGMVTTATTLTWALLLM 324

  Fly   345 LRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNG 409
            :..|...||||.|:|:|:|:.|.|.:.|..::|.|.:.|.|..|...|.||......:.|:|:..
  Rat   325 ILYPDVQRRVQQEIDEVIGQVRCPEMTDQAHMPYTNAVIHEVQRFGDIAPLNLPRITSCDIEVQD 389

  Fly   410 YTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLARM 474
            :.||.|:.:|..::||..|..:||||..|.|..|:|.:|...|.|.|:||..|||.|||:.||||
  Rat   390 FVIPKGTTLIINLSSVLKDETVWEKPHRFHPEHFLDAQGNFVKHEAFMPFSAGRRACLGEPLARM 454

  Fly   475 ELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRRPLG 523
            ||||||...:..|..::|.|||.||..|.....:.|..:::|...|..|
  Rat   455 ELFLFFTCLLQRFSFSVPVGQPRPSTHGFFAFPVAPLPYQLCAVVREQG 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	152/445 (34%)
Cyp2d1	NP_695225.1	CYP2D	68..495	CDD:410756	153/446 (34%)