DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp2ad2

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_694486.1	Gene:	cyp2ad2 / 259306	ZFINID:	ZDB-GENE-020812-2	Length:	492	Species:	Danio rerio

Alignment Length:	505	Identity:	160/505 - (31%)
Similarity:	259/505 - (51%)	Gaps:	44/505 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 MVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTRFMELAKQYGSLFSTRL 92
            :|||       ::..:::| |.....|||||.||.:|.:......|:..  :|||.||.:||.|:
Zfish    20 VVFL-------IIAEMIKN-RTPSNYPPGPWPLPFLGTVFTKMDFKNIN--KLAKVYGKVFSLRV 74

  Fly    93 GSQLTVVMSDYKMIRECF--RREEFTGRPDTP-FMQTLNGYGIINSTGKLWKDQRRFLHDKLRQF 154
            ||:..:::|.|||::|..  :.:.|..||..| |.:...|.|:..|.|.:|:..|||....||.|
Zfish    75 GSEKMIIVSGYKMVKEALVTQNDSFVLRPPVPLFHKVYKGIGLTMSNGYIWRSHRRFAASHLRTF 139

  Fly   155 GMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKF 219
                 |.||:.::..|..|. .::.....::.:|.:...::..||||.:..|....||..:|..:
Zfish   140 -----GEGKKNLELGIQQEC-VYLCDAFKAEKEPFNPIFILHGAVSNTVACLTFGQRFDYNDEWY 198

  Fly   220 RRFNFLIEEGMRLFGEIHT---------VDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDD 275
            :....|..:.::|.|....         :||:|         ....|:..|..::.:..:|.|..
Zfish   199 QEILRLDNQCVQLAGSPRVQLYNAFPKLLDYLP---------GPHQKVFSNYKKITQSLKDEIIK 254

  Fly   276 HKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWI 340
            |:..:||.|.||.:|.||.|:||.|::..     .|.|.|..::. .:|:..||.||..|||.|.
Zfish   255 HREDWDPANPRDFIDNYLTEMEKKKSDPQ-----AGFNIESLIIS-CLDIVEAGTETGATTLRWG 313

  Fly   341 NVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDV 405
            .:||::.|:..::||.|:|:|:|:.|.|.::|...:|.||:.:.|..|...:|||........|.
Zfish   314 LLFMIKFPEIQKKVQAEIDRVIGQSRQPCLDDRVNMPYTEAVLHEIQRFGDVVPLGFPKQAAVDT 378

  Fly   406 ELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDV 470
            ::..|.||.|:.:...::||..|||.||.|:.|.|..|:|..|:.||.:.|:||..|:|.|:|::
Zfish   379 KIGNYFIPKGTSITTNLSSVLHDPNEWETPDTFNPGHFLDKNGQFRKRDAFLPFSAGKRACVGEL 443

  Fly   471 LARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRR 520
            |||..|||||.|.:..|.::...|:. |||:|.:..|..|..|::.:..|
Zfish   444 LARNVLFLFFTSLLQQFTLSKCPGEE-PSLEGEIWFTYAPAPFRISVSVR 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	154/474 (32%)
cyp2ad2	NP_694486.1	p450	38..470	CDD:278495	147/455 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm24427
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820