DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp18a1 and Cyp1b1

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_037072.1	Gene:	Cyp1b1 / 25426	RGDID:	2460	Length:	543	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	167/527 - (31%)
Similarity:	264/527 - (50%)	Gaps:	34/527 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LRQLQVQQDGDAQHLLMVFLGLLALVTLLQWLVRNYRELRK---LPPGPWGLPVIGYLLFMGSEK 73
            |..|..||.     :|::.:.:||:|.|.|||:|.:|  ||   .||||:..|:||....:|...
  Rat    13 LSSLSTQQT-----ILLLLVSVLAIVHLGQWLLRQWR--RKPWSSPPGPFPWPLIGNAASVGRAS 70

  Fly    74 HTRFMELAKQYGSLFSTRLGSQLTVVMSDYKMIRECFRRE--EFTGRPDTPFMQTLNG-----YG 131
            |..|..||::||.:|..||||...||::....|.:...::  .|..||.....:.::|     :|
  Rat    71 HLYFARLARRYGDVFQIRLGSCPVVVLNGESAIHQALVQQGGVFADRPPFASFRVVSGGRSLAFG 135

  Fly   132 IINSTGKLWKDQRRFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHL--HASDGQPVDMSPV 194
               ...:.||::||..:..:|.|. |.....:..::...:.|..|.:..|  ..:.|..:|.:..
  Rat   136 ---HYSERWKERRRAAYGTMRAFS-TRHPRSRGLLEGHALGEARELVAVLVRRCAGGACLDPTQP 196

  Fly   195 ISVAVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPS-ISTAKNKI 258
            |.|||:||:.::....|::.||.:|.......||..|..|....||.:|.:|.||: :.|...:.
  Rat   197 IIVAVANVMSAVCFGCRYNHDDAEFLELLSHNEEFGRTVGAGSLVDVMPWLQLFPNPVRTIFREF 261

  Fly   259 AQNRAEMQRFYQDVIDDHKRSFDPNNI-RDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVI 322
            .|.......|..|....|:.|..|... ||::|.::...|| ||.|...:...|.:.|: :...|
  Rat   262 EQINRNFSNFVLDKFLRHRESLVPGAAPRDMMDAFILSAEK-KATGDPGDSPSGLDLED-VPATI 324

  Fly   323 IDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESM 387
            .|:|.|..:|:.|.|||:.:...|.|....|||.||||||||.|||.:.|...||...:.:.|||
  Rat   325 TDIFGASQDTLSTALLWLLILFTRYPDVQARVQAELDQVVGRDRLPCMSDQPNLPYVMAFLYESM 389

  Fly   388 RRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLIN--SVHMDPNLWEKPEEFRPSRFIDTEGKV 450
            |.:|.:|:...|:.|.:..:.||.||  .:.:..:|  ||:.||..|..||:|.|:||:|.:|.:
  Rat   390 RFTSFLPVTLPHATTANTFVLGYYIP--KNTVVFVNQWSVNHDPAKWSNPEDFDPARFLDKDGFI 452

  Fly   451 RK--PEYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESF 513
            .|  ....:.|.||:|.|:|:.|::..||||.:...|..:....:.:| .::..:.|.:|.|:||
  Rat   453 NKALASSVMIFSVGKRRCIGEELSKTLLFLFISILAHQCNFKANQNEP-SNMSFSYGLSIKPKSF 516

  Fly   514 KVCLKRR 520
            |:.:..|
  Rat   517 KIHVSLR 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	150/477 (31%)
Cyp1b1	NP_037072.1	CYP1B1-like	81..518	CDD:410768	137/445 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920