Protein Alignment Cyp18a1 and Cyp2e1

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_113731.2
• Gene: Cyp2e1 / 25086
• RGDID: 2475
• Length: 493
• Species: Rattus norvegicus
• Alignment Length: 509
• Identity: 158/509 - (31%)
• Similarity: 264/509 - (51%)
• Gaps: 47/509 - (9%)

  Fly    27 LMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTR-FMELAKQYGSLFST 90
            |:|::..|.::::.:.:..::    .|||||:.||::|.:..:..:...: |.:|||::|.:|:.
  Rat    10 LLVWVATLLVISIWKQIYNSW----NLPPGPFPLPILGNIFQLDLKDIPKSFTKLAKRFGPVFTL 70

  Fly    91 RLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTLNGYGIINSTGKLWKDQRRFLHDKLRQ 153
            .|||:..||:..||.::|..  .:.||:||.|.|..|.....|||.:.|..|||.|||....||.
  Rat    71 HLGSRRIVVLHGYKAVKEVLLNHKNEFSGRGDIPVFQEYKNKGIIFNNGPTWKDVRRFSLSILRD 135

  Fly   154 FGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPK 218
            :||     |||..:.||..|....:..|..:.|||.|.:.:|..|..|||..::.:.||..:|.|
  Rat   136 WGM-----GKQGNEARIQREAQFLVEELKKTKGQPFDPTFLIGCAPCNVIADILFNKRFDYNDKK 195

  Fly   219 FRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSIST-------AKNKIAQNRAEMQRFYQDVIDDH 276
            ..|.       |.||.|...:...|.:|.:.:.:.       :..||.:|.:|::::..:...:|
  Rat   196 CLRL-------MSLFNENFYLLSTPWIQLYNNFADYLRYLPGSHRKIMKNVSEIKQYTLEKAKEH 253

  Fly   277 KRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHE-------EQLVQVIIDLFSAGMETIK 334
            .:|.|.|..||:.|..|.|:||.|             |.       |.:...:.|||.||.||..
  Rat   254 LQSLDINCARDVTDCLLIEMEKEK-------------HSQEPMYTMENVSVTLADLFFAGTETTS 305

  Fly   335 TTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTH 399
            |||.:..:.:::.|:...::.:|:|:|:|..|:|.:.|...:|..::.:.|..|..::||....|
  Rat   306 TTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRVPAVRDRLDMPYMDAVVHEIQRFINLVPSNLPH 370

  Fly   400 SPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRR 464
            ..|||....||.||.|:.|||.::|:..|.:.:..||:|:|..|::..||.:..:||..|..|:|
  Rat   371 EATRDTVFQGYVIPKGTVVIPTLDSLLYDSHEFPDPEKFKPEHFLNENGKFKYSDYFKAFSAGKR 435

  Fly   465 MCLGDVLARMELFLFFASFMHCFDI-ALPEGQPLPSLKGNVGATITPESFKVCL 517
            :|:|:.||||||||..::.:..|:: :|.:.:.:......||....|..||:|:
  Rat   436 VCVGEGLARMELFLLLSAILQHFNLKSLVDPKDIDLSPVTVGFGSIPPQFKLCV 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	141/446 (32%)
Cyp2e1	NP_113731.2	CYP2C-like	64..487	CDD:410758	141/447 (32%)