DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2e1

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_113731.2	Gene:	Cyp2e1 / 25086	RGDID:	2475	Length:	493	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	158/509 - (31%)
Similarity:	264/509 - (51%)	Gaps:	47/509 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTR-FMELAKQYGSLFST 90
            |:|::..|.::::.:.:..::    .|||||:.||::|.:..:..:...: |.:|||::|.:|:.
  Rat    10 LLVWVATLLVISIWKQIYNSW----NLPPGPFPLPILGNIFQLDLKDIPKSFTKLAKRFGPVFTL 70

  Fly    91 RLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTLNGYGIINSTGKLWKDQRRFLHDKLRQ 153
            .|||:..||:..||.::|..  .:.||:||.|.|..|.....|||.:.|..|||.|||....||.
  Rat    71 HLGSRRIVVLHGYKAVKEVLLNHKNEFSGRGDIPVFQEYKNKGIIFNNGPTWKDVRRFSLSILRD 135

  Fly   154 FGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPK 218
            :||     |||..:.||..|....:..|..:.|||.|.:.:|..|..|||..::.:.||..:|.|
  Rat   136 WGM-----GKQGNEARIQREAQFLVEELKKTKGQPFDPTFLIGCAPCNVIADILFNKRFDYNDKK 195

  Fly   219 FRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSIST-------AKNKIAQNRAEMQRFYQDVIDDH 276
            ..|.       |.||.|...:...|.:|.:.:.:.       :..||.:|.:|::::..:...:|
  Rat   196 CLRL-------MSLFNENFYLLSTPWIQLYNNFADYLRYLPGSHRKIMKNVSEIKQYTLEKAKEH 253

  Fly   277 KRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHE-------EQLVQVIIDLFSAGMETIK 334
            .:|.|.|..||:.|..|.|:||.|             |.       |.:...:.|||.||.||..
  Rat   254 LQSLDINCARDVTDCLLIEMEKEK-------------HSQEPMYTMENVSVTLADLFFAGTETTS 305

  Fly   335 TTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTH 399
            |||.:..:.:::.|:...::.:|:|:|:|..|:|.:.|...:|..::.:.|..|..::||....|
  Rat   306 TTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRVPAVRDRLDMPYMDAVVHEIQRFINLVPSNLPH 370

  Fly   400 SPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRR 464
            ..|||....||.||.|:.|||.::|:..|.:.:..||:|:|..|::..||.:..:||..|..|:|
  Rat   371 EATRDTVFQGYVIPKGTVVIPTLDSLLYDSHEFPDPEKFKPEHFLNENGKFKYSDYFKAFSAGKR 435

  Fly   465 MCLGDVLARMELFLFFASFMHCFDI-ALPEGQPLPSLKGNVGATITPESFKVCL 517
            :|:|:.||||||||..::.:..|:: :|.:.:.:......||....|..||:|:
  Rat   436 VCVGEGLARMELFLLLSAILQHFNLKSLVDPKDIDLSPVTVGFGSIPPQFKLCV 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	153/480 (32%)
Cyp2e1	NP_113731.2	CYP2C-like	64..487	CDD:410758	141/447 (32%)
Cyp2e1	NP_113731.2	Substrate binding. /evidence=ECO:0000250	298..303		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920