DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2d2

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_036862.2	Gene:	Cyp2d2 / 25053	RGDID:	2471	Length:	500	Species:	Rattus norvegicus

Alignment Length:	511	Identity:	178/511 - (34%)
Similarity:	266/511 - (52%)	Gaps:	47/511 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 VFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHT-RFMELAKQYGSLFSTRL 92
            :||.|:.||...::...:|      ||||..||.:|.||.:..|... ...:|..:||.:||.::
  Rat    18 IFLLLVDLVHRHKFWTAHY------PPGPVPLPGLGNLLQVDFENMPYSLYKLRSRYGDVFSLQI 76

  Fly    93 GSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTLNGYG------IINSTGKLWKDQRRFLHD 149
            ..:..||::..|.:||..  ..|:...||..|....| |||      ::...|..|::||||...
  Rat    77 AWKPVVVINGLKAVRELLVTYGEDTADRPLLPIYNHL-GYGNKSKGVVLAPYGPEWREQRRFSVS 140

  Fly   150 KLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHL---HASDGQ-PVDMSPVISVAVSNVICSLMMST 210
            .||.||:     ||:.:::.:..|.    |||   .|.:.: |.:.|.::|.||||||.||:.:.
  Rat   141 TLRDFGV-----GKKSLEQWVTEEA----GHLCDTFAKEAEHPFNPSILLSKAVSNVIASLVYAR 196

  Fly   211 RFSIDDPKFRRFNFLIEEGMRLFGE-----IHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQ 270
            ||..:||.|.|....::|.   |||     ...::.||.:...|.:   ..|:............
  Rat   197 RFEYEDPFFNRMLKTLKES---FGEDTGFMAEVLNAIPILLQIPGL---PGKVFPKLNSFIALVD 255

  Fly   271 DVIDDHKRSFDP-NNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIK 334
            .::.:||:|:|| ...||:.|.:|.|::|||  |.....|    ::|.|..|:||||.|||.|..
  Rat   256 KMLIEHKKSWDPAQPPRDMTDAFLAEMQKAK--GNPESSF----NDENLRLVVIDLFMAGMVTTS 314

  Fly   335 TTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTH 399
            |||.|..:.|:.:|...|||.:|:|:|:|:.|.|.:.|...:|.|.:.|.|..|.:.|||....|
  Rat   315 TTLSWALLLMILHPDVQRRVHEEIDEVIGQVRRPEMADQARMPFTNAVIHEVQRFADIVPTNIPH 379

  Fly   400 SPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRR 464
            ..:||::..|:.||.|:.:||.::||..|..:||||..|.|..|:|.:|...|.|.|:||..|||
  Rat   380 MTSRDIKFQGFLIPKGTTLIPNLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSAGRR 444

  Fly   465 MCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRR 520
            .|||:.||||||||||...:..|..::..|:|.||..|.....:||:.:::|...|
  Rat   445 ACLGEPLARMELFLFFTCLLQRFSFSVLAGRPRPSTHGVYALPVTPQPYQLCAVAR 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	170/481 (35%)
Cyp2d2	NP_036862.2	CYP2D	68..495	CDD:410756	159/448 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	304	1.000	Domainoid score	I1330
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45879
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810