Protein Alignment Cyp18a1 and Cyp2d2

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_036862.2
• Gene: Cyp2d2 / 25053
• RGDID: 2471
• Length: 500
• Species: Rattus norvegicus
• Alignment Length: 511
• Identity: 178/511 - (34%)
• Similarity: 266/511 - (52%)
• Gaps: 47/511 - (9%)

  Fly    29 VFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHT-RFMELAKQYGSLFSTRL 92
            :||.|:.||...::...:|      ||||..||.:|.||.:..|... ...:|..:||.:||.::
  Rat    18 IFLLLVDLVHRHKFWTAHY------PPGPVPLPGLGNLLQVDFENMPYSLYKLRSRYGDVFSLQI 76

  Fly    93 GSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTLNGYG------IINSTGKLWKDQRRFLHD 149
            ..:..||::..|.:||..  ..|:...||..|....| |||      ::...|..|::||||...
  Rat    77 AWKPVVVINGLKAVRELLVTYGEDTADRPLLPIYNHL-GYGNKSKGVVLAPYGPEWREQRRFSVS 140

  Fly   150 KLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHL---HASDGQ-PVDMSPVISVAVSNVICSLMMST 210
            .||.||:     ||:.:::.:..|.    |||   .|.:.: |.:.|.::|.||||||.||:.:.
  Rat   141 TLRDFGV-----GKKSLEQWVTEEA----GHLCDTFAKEAEHPFNPSILLSKAVSNVIASLVYAR 196

  Fly   211 RFSIDDPKFRRFNFLIEEGMRLFGE-----IHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQ 270
            ||..:||.|.|....::|.   |||     ...::.||.:...|.:   ..|:............
  Rat   197 RFEYEDPFFNRMLKTLKES---FGEDTGFMAEVLNAIPILLQIPGL---PGKVFPKLNSFIALVD 255

  Fly   271 DVIDDHKRSFDP-NNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIK 334
            .::.:||:|:|| ...||:.|.:|.|::|||  |.....|    ::|.|..|:||||.|||.|..
  Rat   256 KMLIEHKKSWDPAQPPRDMTDAFLAEMQKAK--GNPESSF----NDENLRLVVIDLFMAGMVTTS 314

  Fly   335 TTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTH 399
            |||.|..:.|:.:|...|||.:|:|:|:|:.|.|.:.|...:|.|.:.|.|..|.:.|||....|
  Rat   315 TTLSWALLLMILHPDVQRRVHEEIDEVIGQVRRPEMADQARMPFTNAVIHEVQRFADIVPTNIPH 379

  Fly   400 SPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRR 464
            ..:||::..|:.||.|:.:||.::||..|..:||||..|.|..|:|.:|...|.|.|:||..|||
  Rat   380 MTSRDIKFQGFLIPKGTTLIPNLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSAGRR 444

  Fly   465 MCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRR 520
            .|||:.||||||||||...:..|..::..|:|.||..|.....:||:.:::|...|
  Rat   445 ACLGEPLARMELFLFFTCLLQRFSFSVLAGRPRPSTHGVYALPVTPQPYQLCAVAR 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	158/447 (35%)
Cyp2d2	NP_036862.2	CYP2D	68..495	CDD:410756	159/448 (35%)