DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2c12

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_113760.2	Gene:	Cyp2c12 / 25011	RGDID:	2470	Length:	490	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	155/509 - (30%)
Similarity:	244/509 - (47%)	Gaps:	46/509 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIG-YLLFMGSEKHTRFMELAKQYGSLFST 90
            :::.|.|..|:.|..|  |......||||||..||:.| :|.....:........:|.||.:|:.
  Rat     5 VVLVLSLSFLLLLYLW--RPSPGRGKLPPGPTPLPIFGNFLQIDMKDIRQSISNFSKTYGPVFTL 67

  Fly    91 RLGSQLTVVMSDYKMIRECF--RREEFTGRPDTP-FMQTLNGYGIINSTGKLWKDQRRFLHDKLR 152
            ..|||.|||:..|:.::|..  ..|||:||...| |.:...|.||..|.|.:|:..|.|..:.||
  Rat    68 YFGSQPTVVLHGYEAVKEALIDYGEEFSGRGRMPVFEKATKGLGISFSRGNVWRATRHFTVNTLR 132

  Fly   153 QFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDP 217
            ..||     ||:.::.::..|....:..|..:.|.|.|...:|..|..|||||::...||   |.
  Rat   133 SLGM-----GKRTIEIKVQEEAEWLVMELKKTKGSPCDPKFIIGCAPCNVICSIIFQNRF---DY 189

  Fly   218 KFRRFNFLIEEGMRLFGEIHTVDYI-----PTMQCFPSISTAKNKIAQNR-------AEMQRFYQ 270
            |.:.|..|||         :..:||     |..|.|.:.....:....|.       |.::.:..
  Rat   190 KDKDFLSLIE---------NVNEYIKIVSTPAFQVFNAFPILLDYCPGNHKTHSKHFAAIKSYLL 245

  Fly   271 DVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKT 335
            ..|.:|:.|.|.:|.||.:|::|  |::.:..|.....:.    :|.|..::.:||..|.||...
  Rat   246 KKIKEHEESLDVSNPRDFIDYFL--IQRCQENGNQQMNYT----QEHLAILVTNLFIGGTETSSL 304

  Fly   336 TLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHS 400
            ||.:..:.:::.|....:||:|:.||:||||.|.:.|..::|.|.:.|.|..|...:.|....|.
  Rat   305 TLRFALLLLMKYPHITDKVQEEIGQVIGRHRSPCMLDRIHMPYTNAMIHEVQRYIDLAPNGLLHE 369

  Fly   401 PTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRM 465
            .|.|.:...|.||.|:.|:..:.||..|...:..||.|.|..|:|..|..:|.:||:||..|:|.
  Rat   370 VTCDTKFRDYFIPKGTAVLTSLTSVLHDSKEFPNPEMFDPGHFLDENGNFKKSDYFMPFSAGKRK 434

  Fly   466 CLGDVLARMELFLFFASFMHCF---DIALPEGQPLPSLKGNVGATITPESFKVC 516
            |:|:.||.||||||..:.:..|   .::.|:...:.|::....:  .|.:|::|
  Rat   435 CVGEGLASMELFLFLTTILQNFKLKSLSDPKDIDINSIRSEFSS--IPPTFQLC 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	147/482 (30%)
Cyp2c12	NP_113760.2	CYP2C-like	61..485	CDD:410758	137/448 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910