Protein Alignment Cyp18a1 and Cyp2a2

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_036825.1
• Gene: Cyp2a2 / 24895
• RGDID: 2464
• Length: 492
• Species: Rattus norvegicus
• Alignment Length: 485
• Identity: 148/485 - (30%)
• Similarity: 252/485 - (51%)
• Gaps: 38/485 - (7%)

  Fly    22 DAQHLLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIG-YLLFMGSEKHTRFMELAKQYG 85
            |...||:|.|..|:::.|:....:..||  :|||||..||.|| ||.....:.::...:|:::||
  Rat     3 DTGLLLVVILASLSVMFLVSLWQQKIRE--RLPPGPTPLPFIGNYLQLNMKDVYSSITQLSERYG 65

  Fly    86 SLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTL-NGYGIINSTGKLWKDQRRFL 147
            .:|:..||.:..||:..|..::|..  :.|||:||.:.|....| .|||...|..:..|..|||.
  Rat    66 PVFTIHLGPRRIVVLYGYDAVKEALVDQAEEFSGRGELPTFNILFKGYGFSLSNVEQAKRIRRFT 130

  Fly   148 HDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRF 212
            ...||.||:     ||:.:|:.|:.|....|..|..:.|.|:|.|..:|..|||||.|::...||
  Rat   131 IATLRDFGV-----GKRDVQECILEEAGYLIKTLQGTCGAPIDPSIYLSKTVSNVINSIVFGNRF 190

  Fly   213 SIDDPKFRRFNFLIEEGMRLF-----GEI----HTV-DYIPTMQCFPSISTAKNKIAQNRAEMQR 267
            ..:|.:|.....:|:| |.:|     |::    |:| .|:|..|         .:|.:...:::.
  Rat   191 DYEDKEFLSLLEMIDE-MNIFAASATGQLYDMFHSVMKYLPGPQ---------QQIIKVTQKLED 245

  Fly   268 FYQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMET 332
            |..:.:..:..:.|||:.|:.:|.:|..:::.|       ..:.:.|...||...:.|..||..:
  Rat   246 FMIEKVRQNHSTLDPNSPRNFIDSFLIRMQEEK-------YVNSEFHMNNLVMSSLGLLFAGTGS 303

  Fly   333 IKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLAT 397
            :.:||....:.::::|....:|.:|:::|:||:|.|..||...:|.|::.|.|..|.|::.||..
  Rat   304 VSSTLYHGFLLLMKHPDVEAKVHEEIERVIGRNRQPQYEDHMKMPYTQAVINEIQRFSNLAPLGI 368

  Fly   398 THSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVG 462
            .....::....|:.:|.|:.|.|:|.|:..:|..:...::|.|..|:|.:|:::|...|:||.:|
  Rat   369 PRRIIKNTTFRGFFLPKGTDVFPIIGSLMTEPKFFPNHKDFNPQHFLDDKGQLKKNAAFLPFSIG 433

  Fly   463 RRMCLGDVLARMELFLFFASFMHCFDIALP 492
            :|.||||.||:|||||...:.:..|....|
  Rat   434 KRFCLGDSLAKMELFLLLTTILQNFRFKFP 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	126/421 (30%)
Cyp2a2	NP_036825.1	CYP2A	64..487	CDD:410761	127/422 (30%)