DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2a1

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_036824.1	Gene:	Cyp2a1 / 24894	RGDID:	2463	Length:	492	Species:	Rattus norvegicus

Alignment Length:	485	Identity:	147/485 - (30%)
Similarity:	254/485 - (52%)	Gaps:	38/485 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DAQHLLMVFLGLLA---LVTLLQWLVRNYRELRKLPPGPWGLPVIG-YLLFMGSEKHTRFMELAK 82
            |...||:|.|..|:   ||:|.|..:|.     :|||||..||.|| ||.....:.::...:|::
  Rat     3 DTGLLLVVILASLSVMLLVSLWQQKIRG-----RLPPGPTPLPFIGNYLQLNTKDVYSSITQLSE 62

  Fly    83 QYGSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTL-NGYGIINSTGKLWKDQR 144
            :||.:|:..||.:..||:..|..::|..  :.|||:||.:.....|| .|||:..|:|:..|..|
  Rat    63 RYGPVFTIHLGPRRVVVLYGYDAVKEALVDQAEEFSGRGEQATYNTLFKGYGVAFSSGERAKQLR 127

  Fly   145 RFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMS 209
            |.....||.||:     ||:.:::||:.|....|..|..:.|.|:|.:..:|..|||||.|::..
  Rat   128 RLSIATLRDFGV-----GKRGVEERILEEAGYLIKMLQGTCGAPIDPTIYLSKTVSNVISSIVFG 187

  Fly   210 TRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSISTA-------KNKIAQNRAEMQR 267
            .||..:|.:|...       :::.|:::.....||.|.:....:.       :.:|.:...:::.
  Rat   188 ERFDYEDTEFLSL-------LQMMGQMNRFAASPTGQLYDMFHSVMKYLPGPQQQIIKVTQKLED 245

  Fly   268 FYQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMET 332
            |..:.:..:..:.|||:.|:.:|.:|..:::.|...::.       |.:.||...:.||.||.||
  Rat   246 FMIEKVRQNHSTLDPNSPRNFIDSFLIRMQEEKNGNSEF-------HMKNLVMTTLSLFFAGSET 303

  Fly   333 IKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLAT 397
            :.:||.:..:.::::|....:|.:|::||:||:|.|..||...:|.|::.|.|..|.|::.||..
  Rat   304 VSSTLRYGFLLLMKHPDVEAKVHEEIEQVIGRNRQPQYEDHMKMPYTQAVINEIQRFSNLAPLGI 368

  Fly   398 THSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVG 462
            .....::....|:.:|..:.|.|::.|:..||..:..|::|.|..|:|.:|:::|...|:||..|
  Rat   369 PRRIIKNTTFRGFFLPKATDVFPILGSLMTDPKFFPSPKDFDPQNFLDDKGQLKKNAAFLPFSTG 433

  Fly   463 RRMCLGDVLARMELFLFFASFMHCFDIALP 492
            :|.||||.||:|||||...:.:..|....|
  Rat   434 KRFCLGDGLAKMELFLLLTTILQNFRFKFP 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	135/450 (30%)
Cyp2a1	NP_036824.1	p450	33..489	CDD:278495	135/450 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm45879
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720