Protein Alignment Cyp18a1 and Cyp2r1

DIOPT Version :9

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_796356.2
• Gene: Cyp2r1 / 244209
• MGIID: 2449771
• Length: 501
• Species: Mus musculus
• Alignment Length: 505
• Identity: 160/505 - (31%)
• Similarity: 252/505 - (49%)
• Gaps: 40/505 - (7%)

  Fly    33 LLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYL--LFMGSE-KHTRFMELAKQYGSLFSTRLGS 94
            ||..|.:::.|:|. |.....||||..||.:|.:  |.:.:: .|....:.::.||.:||..||.
Mouse    20 LLLFVLVVRQLLRQ-RRPAGFPPGPPRLPFVGNICSLALSADLPHVYMRKQSRVYGEIFSLDLGG 83

  Fly    95 QLTVVMSDYKMIRECF--RREEFTGRPDTP-FMQTLNGYGIINST-GKLWKDQRRFLHDKLRQFG 155
            ..|||::.|.:::||.  :.|.|..||..| ||:.....|::||. |:.|.|.||...:...
Mouse    84 ISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWIDHRRLAVNSFH--- 145

  Fly   156 MTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKFR 220
              |.|:|::..:.:|:.|....|..:....|.|.|:..:|:.||||:...::...||:.:|..|:
Mouse   146 --YFGSGQKSFESKILEETWSLIDAIETYKGGPFDLKQLITNAVSNITNLILFGERFTYEDTDFQ 208

  Fly   221 RFNFLIEEGMRLFGEIHTVDYIPTMQCFPSIST----AKNKIAQNRAEMQRFYQDVIDDHKRSFD 281
            ....|..|.:.|........|    ..||.|..    ...::.:|...:..|...:|:....:..
Mouse   209 HMIELFSENVELAASAPVFLY----NAFPWIGILPFGKHQRLFRNADVVYDFLSRLIEKAAVNRK 269

  Fly   282 PNNIRDLVDFYLCEIEKAKAEGTDAELFDGKN------HEEQLVQVIIDLFSAGMETIKTTLLWI 340
            |:.....||.||.|:::            |:|      .:|.|:..:.:|..||.||....|.|.
Mouse   270 PHLPHHFVDAYLDEMDQ------------GQNDPLSTFSKENLIFSVGELIIAGTETTTNVLRWA 322

  Fly   341 NVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDV 405
            .:||...|....:|..|:|.:||.:|.|:.|....:|.||:.:.|.:|..:||||...|:.:.|.
Mouse   323 ILFMALYPNIQGQVHKEIDLIVGHNRRPSWEYKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDA 387

  Fly   406 ELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDV 470
            .:.||:||.|:.||..:.|||.|...|:.|:.|.|.||:|:.|...|.|..|||.:|||.|||:.
Mouse   388 VVRGYSIPKGTTVITNLYSVHFDEKYWKDPDMFYPERFLDSNGYFTKKEALIPFSLGRRHCLGEQ 452

  Fly   471 LARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRR 520
            |||||:||||.|.:..|.:..|. :.:|:||..:|.|:.|:.:.:|.:||
Mouse   453 LARMEMFLFFTSLLQQFHLHFPH-ELVPNLKPRLGMTLQPQPYLICAERR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	151/479 (32%)
Cyp2r1	NP_796356.2	p450	40..497	CDD:278495	151/478 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	290	1.000	Domainoid score	I1539
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	302	1.000	Inparanoid score	I2648
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43796
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24300
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.970