DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2b23

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001074617.1	Gene:	Cyp2b23 / 243881	MGIID:	3646735	Length:	491	Species:	Mus musculus

Alignment Length:	513	Identity:	160/513 - (31%)
Similarity:	260/513 - (50%)	Gaps:	54/513 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LLALVT-LLQWLVRNY-RELRKLPPGPWGLPVIGYLLFM---GSEKHTRFMELAKQYGSLFSTRL 92
            ||||:| .|..|:|.. :...:|||||..||.:|.||.|   |..|  .|::|..::|.:|:..|
Mouse     8 LLALLTGFLLLLIRGQPKAYSRLPPGPRPLPFLGNLLQMDRGGLLK--SFIKLRDKHGDVFTVHL 70

  Fly    93 GSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTL-NGYGIINSTGKLWKDQRRFLHDKLRQF 154
            |.:..|::...:.|:|..  ..:.|:||.....:|.: ..||:|.|:|:.||..|||....:|.|
Mouse    71 GPRPVVMLYGTETIKEALVDHSDAFSGRGAIAVIQPIVQDYGVIFSSGERWKTLRRFSLATMRDF 135

  Fly   155 GMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKF 219
            ||     ||:.:::||..|....:..|...:|.|:|.:.:.....:|:|||::...||...|.:|
Mouse   136 GM-----GKRSVEERIKEEAQCLVEELKKYEGAPLDPTFLFQCITANIICSIVFGERFDYTDHQF 195

  Fly   220 RRFNFLIEEGMRLFGEIHTVD-YIPTMQCFPSIST---------------AKNKIAQNRAEMQRF 268
                            :|.:| :..|:....|.|:               ...:|::|..|:..:
Mouse   196 ----------------LHLLDLFYQTLSLISSFSSQLFELFSAVLKYFPGTHRQISKNIQEILNY 244

  Fly   269 YQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETI 333
            ....::.||.:.||:..||.:|.||..:||.|:.      ...:.|.:.|:..::.||.||.||.
Mouse   245 IGHSVEQHKATLDPSAPRDFIDTYLLRMEKEKSN------HHTEFHHQNLLISVLSLFFAGTETT 303

  Fly   334 KTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATT 398
            .|||.:..:.||:.|....:||.|:|||:..|.:||:||...:|.||:.|.|..|.|.:.|:...
Mouse   304 STTLRYGFLLMLKYPHVAEKVQKEIDQVISAHHVPTLEDRIKMPYTEAVIHEIQRFSDLAPIGLP 368

  Fly   399 HSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGR 463
            |:.|:|....||.:|..:.|.|:::|...||..:|:|::|.|..|:|..|.::|.|.|:||..|:
Mouse   369 HTVTKDTVFRGYLLPKNTEVYPILSSALHDPQYFEQPDKFNPEHFLDANGALKKSEAFLPFSTGK 433

  Fly   464 RMCLGDVLARMELFLFFASFMHCFDIALPEG-QPLPSLKGNVGATITPESFKVCLKRR 520
            |:|||:.:||.||||||.:.:..|.::.|.. :.:.......|....|..:::|...|
Mouse   434 RICLGEGIARNELFLFFTALLQNFSLSSPVAPEDIDLTPKESGFVKIPPVYRICFLPR 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	149/485 (31%)
Cyp2b23	NP_001074617.1	p450	39..488	CDD:278495	143/477 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm43796
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720