Protein Alignment Cyp18a1 and Cyp4a2

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_001038235.1
• Gene: Cyp4a2 / 24306
• RGDID: 2479
• Length: 504
• Species: Rattus norvegicus
• Alignment Length: 523
• Identity: 123/523 - (23%)
• Similarity: 207/523 - (39%)
• Gaps: 106/523 - (20%)

  Fly    26 LLMVFLGLLALVTLL---QWLVRNYRELRKLPPGP----WGLPVIGYLLFMGSEKHTRFME---- 79
            ||.:||.|...|...   |||:   :.|.|.|..|    ||          .:.|...|.:
  Rat    24 LLSLFLVLFKAVQFYLRRQWLL---KALEKFPSTPSHWLWG----------HNLKDREFQQVLTW 75

  Fly    80 LAKQYGSLFSTRLGSQLTVVMSDYKMIRECFRREEFTGRPDTPFMQTLN---GYGIINSTGKLWK 141
            :.|..|:......||...|::.|...::...      ||.|....|:|.   |||::...||.|.
  Rat    76 VEKFPGACLQWLSGSTARVLLYDPDYVKVVL------GRSDPKPYQSLAPWIGYGLLLLNGKKWF 134

  Fly   142 DQRRFL-----HDKLRQFGMTYMGNGKQQMQKRIMTE-VHEFIGHLHASDGQ--PVDMSPVISVA 198
            ..||.|     :|.|:.:             .:||.: |...:......|.|  |:::...:|:.
  Rat   135 QHRRMLTPAFHYDILKPY-------------VKIMADSVSIMLDKWEKLDDQDHPLEIFHYVSLM 186

  Fly   199 VSNVICSLMMSTRFSID-DPKFRRFNFLIEE-GMRLFGEIHTVDY----IPTMQCFPSISTAKNK 257
            ..:.:.....|.:.|:. |...|.:...:|: ...:|..:.:..|    |..|.....:|....:
  Rat   187 TLDTVMKCAFSHQGSVQLDVNSRSYTKAVEDLNNLIFFRVRSAFYGNSIIYNMSSDGRLSRRACQ 251

  Fly   258 IA---------------QNRAEMQRFYQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAE 307
            ||               ||..|:|:..:      ||..|   ..|::.|              |:
  Rat   252 IAHEHTDGVIKTRKAQLQNEEELQKARK------KRHLD---FLDILLF--------------AK 293

  Fly   308 LFDGKNHEEQLVQVIIDLFS-AGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIE 371
            :.|||:..::.::..:|.|. .|.:|..:.:.|:...:..:|:...|.::|:..::|.....|.:
  Rat   294 MEDGKSLSDEDLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSILGDGTSVTWD 358

  Fly   372 DLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPE 436
            .|..:|.|...|.|::|..|.||..:....:.....:|.:||.|..|..||..:|.:|:.|..|:
  Rat   359 HLDQMPYTTMCIKEALRLYSPVPSVSRELSSPVTFPDGRSIPKGIRVTILIYGLHHNPSYWPNPK 423

  Fly   437 EFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQ----PL 497
            .|.||||  :....|....::||..|.|.|:|...|..||.:..|..:..|:: ||:..    |:
  Rat   424 VFDPSRF--SPDSPRHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFEL-LPDPTRIPVPM 485

  Fly   498 PSL 500
            |.|
  Rat   486 PRL 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	105/453 (23%)
Cyp4a2	NP_001038235.1	CYP4B-like	69..499	CDD:410771	107/465 (23%)