DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp1a2

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_036673.3	Gene:	Cyp1a2 / 24297	RGDID:	2459	Length:	513	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	155/527 - (29%)
Similarity:	252/527 - (47%)	Gaps:	72/527 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AQHLLMVFLGLLALVTLLQWLVRNYR----ELRKLPPGPWGLPVIGYLLFMGSEKHTRFMELAKQ 83
            |..||:.    .|:..|:.|::|..|    :..|.||||||||.||::|.:|...|....:|::|
  Rat    10 APELLLA----TAIFCLVFWVLRGTRTQVPKGLKSPPGPWGLPFIGHMLTLGKNPHLSLTKLSQQ 70

  Fly    84 YGSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDT-PFMQTLNGYGII--NSTGKLWKDQ 143
            ||.:...|:||...||:|....|::..  :.::|.||||. .|....||..:.  ..:|.:|..:
  Rat    71 YGDVLQIRIGSTPVVVLSGLNTIKQALVKQGDDFKGRPDLYSFTLITNGKSMTFNPDSGPVWAAR 135

  Fly   144 RRFLHDKLRQFGMT---------YMGNGKQQMQK----------RIMTEVHEFIGHLHASDGQPV 189
            ||...|.|:.|.:.         |:   ::.:.|          ::|.||    ||.     :||
  Rat   136 RRLAQDALKSFSIASDPTSVSSCYL---EEHVSKEANHLISKFQKLMAEV----GHF-----EPV 188

  Fly   190 DMSPVISVAVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHT----VDYIPTMQCFPS 250
            :.   :..:|:|||.::.....|    |:.......:.:..:.|.|..|    ||:.|.::..|:
  Rat   189 NQ---VVESVANVIGAMCFGKNF----PRKSEEMLNLVKSSKDFVENVTSGNAVDFFPVLRYLPN 246

  Fly   251 ISTAKNKIAQNRAEMQRFYQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHE 315
            .:..:.|...:...:  |.|..:.:|.:.|:.|:|:|:........|..|..|       |...:
  Rat   247 PALKRFKNFNDNFVL--FLQKTVQEHYQDFNKNSIQDITGALFKHSENYKDNG-------GLIPQ 302

  Fly   316 EQLVQVIIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITE 380
            |::|.::.|:|.||.||:.|.:.|..:.::..||..|::.:|||.|:||.|.|.:.|...||..|
  Rat   303 EKIVNIVNDIFGAGFETVTTAIFWSILLLVTEPKVQRKIHEELDTVIGRDRQPRLSDRPQLPYLE 367

  Fly   381 STILESMRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLIN--SVHMDPNLWEKPEEFRPSRF 443
            :.|||..|.:|.||....||.|||..|||:.||....:  .||  .|:.|...|:.|..|||.||
  Rat   368 AFILEIYRYTSFVPFTIPHSTTRDTSLNGFHIPKECCI--FINQWQVNHDEKQWKDPFVFRPERF 430

  Fly   444 IDTEGKV---RKPEYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVG 505
            :..:...   ...|..:.||:|:|.|:|::.|:.|:|||.|..:|..:..:|.|..: .|..:.|
  Rat   431 LTNDNTAIDKTLSEKVMLFGLGKRRCIGEIPAKWEVFLFLAILLHQLEFTVPPGVKV-DLTPSYG 494

  Fly   506 ATITPES 512
            .|:.|.:
  Rat   495 LTMKPRT 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	146/492 (30%)
Cyp1a2	NP_036673.3	p450	41..499	CDD:365848	145/488 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920