Protein Alignment Cyp18a1 and Cyp1a1

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_036672.3
• Gene: Cyp1a1 / 24296
• RGDID: 2458
• Length: 524
• Species: Rattus norvegicus
• Alignment Length: 544
• Identity: 171/544 - (31%)
• Similarity: 273/544 - (50%)
• Gaps: 80/544 - (14%)

  Fly    33 LLALVT--LLQWLVRNYR----ELRKLPPGPWGLPVIGYLLFMGSEKHTRFMELAKQYGSLFSTR 91
            |||:.|  |..|:||..|    :..|.||||||||.||::|.:|...|....:|::|||.:...|
  Rat    17 LLAVTTFCLGFWVVRVTRTWVPKGLKSPPGPWGLPFIGHVLTLGKNPHLSLTKLSQQYGDVLQIR 81

  Fly    92 LGSQLTVVMSDYKMIRECF--RREEFTGRPDT-PFMQTLNGYGII--NSTGKLWKDQRRFLHDKL 151
            :||...||:|....|::..  :.::|.||||. .|....||..:.  ..:|.||..:||...:.|
  Rat    82 IGSTPVVVLSGLNTIKQALVKQGDDFKGRPDLYSFTLIANGQSMTFNPDSGPLWAARRRLAQNAL 146

  Fly   152 RQFGMT---------YMGNGKQQMQK----------RIMTEVHEFIGHLHASDGQPVDMSPVISV 197
            :.|.:.         |:   ::.:.|          ::|.||    ||.        |....:.|
  Rat   147 KSFSIASDPTLASSCYL---EEHVSKEAEYLISKFQKLMAEV----GHF--------DPFKYLVV 196

  Fly   198 AVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEI----HTVDYIPTMQCFPSISTAKNKI 258
            :|:||||::....|:..||.:......|..|    |||:    :..|:||.::..|:.|....|.
  Rat   197 SVANVICAICFGRRYDHDDQELLSIVNLSNE----FGEVTGSGYPADFIPILRYLPNSSLDAFKD 257

  Fly   259 AQNRAEMQRFYQDVIDDHKRSFDPNNIRDLVDFYL--CEIEKAKAEGTDAELFDGKNHEEQLVQV 321
            ...:  ...|.:.:|.:|.|:|:..:|||:.|..:  |: ::...|..:.:|.|.|     ::.:
  Rat   258 LNKK--FYSFMKKLIKEHYRTFEKGHIRDITDSLIEHCQ-DRRLDENANVQLSDDK-----VITI 314

  Fly   322 IIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILES 386
            :.|||.||.:||.|.:.|..::::.||:..|::|:|||.|:||.|.|.:.|...||..|:.|||:
  Rat   315 VFDLFGAGFDTITTAISWSLMYLVTNPRIQRKIQEELDTVIGRDRQPRLSDRPQLPYLEAFILET 379

  Fly   387 MRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLIN--SVHMDPNLWEKPEEFRPSRFIDTEGK 449
            .|.||.||....||..||..|||:.||.| |.: .:|  .|:.|..||..|.||||.||:.:.|.
  Rat   380 FRHSSFVPFTIPHSTIRDTSLNGFYIPKG-HCV-FVNQWQVNHDQELWGDPNEFRPERFLTSSGT 442

  Fly   450 VRK--PEYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITP-- 510
            :.|  .|..|.||:|:|.|:|:.:.|:|:|||.|..:...:..:..|:.: .:....|.|:..
  Rat   443 LDKHLSEKVILFGLGKRKCIGETIGRLEVFLFLAILLQQMEFNVSPGEKV-DMTPAYGLTLKHAR 506

  Fly   511 -ESFKVCLKRRPLGPTAADPHHMR 533
             |.|:|.::       ::.|.|::
  Rat   507 CEHFQVQMR-------SSGPQHLQ 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	142/466 (30%)
Cyp1a1	NP_036672.3	Mitochondrial targeting signal. /evidence=ECO:0000269|PubMed:19401463, ECO:0000269|PubMed:9348277	33..44		2/10 (20%)
		CYP1A	74..509	CDD:410769	141/464 (30%)