DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2j12

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001093652.1	Gene:	Cyp2j12 / 242546	MGIID:	3717097	Length:	502	Species:	Mus musculus

Alignment Length:	515	Identity:	166/515 - (32%)
Similarity:	265/515 - (51%)	Gaps:	50/515 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LLALVTLLQWLVRNYRELRK---LPPGPWGLPVIGYLLFMGSEK-HTRFMELAKQYGSLFSTRLG 93
            :||.||.:  |:.:|.:.::   .|||||.||.:|.|..:..|: |....:..|:||:|.|...|
Mouse    22 VLAAVTFM--LLAHYLKTQRPKNYPPGPWRLPFVGNLFQLDLEQPHVVIQQFVKKYGNLTSLDFG 84

  Fly    94 SQLTVVMSDYKMIRECFRREE--FTGRPDTPF-MQTLNGYGIINSTGKLWKDQRRFLHDKLRQFG 155
            :..:|:::...:|:|.|...|  |..||.||. .:..|..|:|.|.|:.||:||||....|:.||
Mouse    85 NIPSVIITGLPLIKEVFTNMEQNFLNRPITPIRKRVFNNNGLIISNGQTWKEQRRFALMTLKNFG 149

  Fly   156 MTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKFR 220
            :     ||:.:::||..|....:..:....|||.|....|:.||||:||:.....||..:|..|
Mouse   150 L-----GKKSLEQRIQKEADCLVEAIGEEKGQPFDPHFKINSAVSNIICTFAFGERFEYEDSHF- 208

  Fly   221 RFNFLIEEGMRLFGEIHTVDYIPTMQC-----FPSI----STAKNKIAQNRAEMQRFYQDVIDDH 276
                  .|.:||..|...::  .:|.|     ||||    ..:...:.:|..:::.|...:::.|
Mouse   209 ------HELLRLLDEATCLE--ASMMCQLYNVFPSIIQYVPGSHQTVLRNWEKLKLFIYQMMESH 265

  Fly   277 KRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWIN 341
            ::.::|:..||.:|.:|.|:.|...:.|.:      .:||.|:...:|||.||.||...||.|..
Mouse   266 RKDWNPDEPRDFIDAFLTEMSKYGDKTTTS------FNEENLINSTLDLFFAGSETTTNTLRWAL 324

  Fly   342 VFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVE 406
            :::..||:...:|..|:|:|:|..|.|:.:|...:|.|.:.|.|.:|..:|:|:......|.|..
Mouse   325 LYITTNPEVQEKVHSEIDRVIGHGRQPSTDDRDSMPYTNAVIHEVLRMGNILPMNVPREVTADST 389

  Fly   407 LNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVL 471
            |.|:.:|.|:.|:..:.::|.||..|..|..|.|..|:: .|:.:|.|.|:||.:|:|.|.|:.|
Mouse   390 LAGFHLPKGTMVLTNLTALHRDPKEWATPNTFNPEHFLE-NGQFKKRESFLPFSLGKRACPGEQL 453

  Fly   472 ARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRRPLGPTAADPHH 531
            ||.|||:||.:.|..|....|..:.| |||...|.|::|.|..:|          |.|.|
Mouse   454 ARSELFIFFTALMQKFTFKPPINEKL-SLKFRNGLTLSPVSHCIC----------AVPRH 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	156/475 (33%)
Cyp2j12	NP_001093652.1	p450	44..497	CDD:278495	156/474 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm43796
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720