DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp18a1 and Cyp2c23

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_017173651.1	Gene:	Cyp2c23 / 226143	MGIID:	1888897	Length:	501	Species:	Mus musculus

Alignment Length:	517	Identity:	165/517 - (31%)
Similarity:	282/517 - (54%)	Gaps:	40/517 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 MVFLGL--LALVTLLQ--WLVRNYRELR---KLPPGPWGLPVIGYLLFMG-SEKHTRFMELAKQY 84
            |..|||  |||:.|:.  .|:..:.::|   :|||||..||:||.:|.:. .:......:|||:|
Mouse     1 MELLGLPTLALLVLVMSLSLLSVWTKMRTGGRLPPGPTPLPIIGNILQLDLKDIPASLSKLAKEY 65

  Fly    85 GSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQ-TLNGYGIINSTGKLWKDQRRF 146
            |.:::...||..|||:..|.:::|..  :.:||.||...|.:: :..|:||:.|.|:.||..|||
Mouse    66 GPVYTLYFGSWPTVVLHGYDVVKEALLNQGDEFLGRGPLPIIEDSQKGHGIVFSEGERWKLLRRF 130

  Fly   147 LHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTR 211
            ....|:.|||     ||:.:::|:..|....:..||.::.||.|.:.:::.|..|||||::.:.|
Mouse   131 SLMTLKNFGM-----GKRSLEERVQEEARCLVEELHKTEAQPFDPTFILACAPCNVICSILFNER 190

  Fly   212 FSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSIST----AKNKIAQNRAEMQRFYQDV 272
            |..:|..|.....|:.:.   |.::::: :|.....:|:|..    ...:.::....::.|..:.
Mouse   191 FPYNDKTFLNLMDLLNKN---FYQLNSI-WIQMYNLWPTIMKYIPGKHREFSKRLGGVKNFILEK 251

  Fly   273 IDDHKRSFDPNNIRDLVDFYLCEIEKAKAE-GTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTT 336
            :.:|:.|.||.|.||.:|.:|.:||:.|.. .:|..|       |.|.....:||:||.||..||
Mouse   252 VKEHQESLDPANPRDYIDCFLSKIEEEKHNLKSDFNL-------ENLAICGSNLFTAGTETTSTT 309

  Fly   337 LLWINVFMLRNP-------KEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVP 394
            |.:..:.::::|       :|..:|.:|||:|:|||:.|:::|...||.|::.:.|..|..:::|
Mouse   310 LRFGLLLLVKHPEVQGTPSEEGAKVHEELDRVIGRHQPPSMKDKMKLPYTDAVLHEIQRYITLLP 374

  Fly   395 LATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPF 459
            .:..|:..:|.:...|.||.|:.|.|.::|:.:|...:..||:|.|..|:|..|..:|.:||:||
Mouse   375 SSLPHAVVQDTKFRHYVIPKGTAVFPFLSSILLDQKEFPNPEKFDPGHFLDKNGCFKKTDYFVPF 439

  Fly   460 GVGRRMCLGDVLARMELFLFFASFMHCFDI-ALPEGQPLPSLKGNVGATITPESFKVCLKRR 520
            .:|:|.|:|:.||||||||||.:.:..|.: ||.|.:.|.......|....|..:|:.|..|
Mouse   440 SLGKRSCVGEGLARMELFLFFTTILQKFSLKALVEPKDLDIKPVTTGLFNLPPPYKLRLVPR 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	152/479 (32%)
Cyp2c23	XP_017173651.1	p450	34..496	CDD:365848	151/477 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820