Protein Alignment Cyp18a1 and Cyp2d34

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: XP_030104365.1
• Gene: Cyp2d34 / 223706
• MGIID: 2385022
• Length: 519
• Species: Mus musculus
• Alignment Length: 525
• Identity: 164/525 - (31%)
• Similarity: 260/525 - (49%)
• Gaps: 52/525 - (9%)

  Fly    28 MVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEK-HTRFMELAKQYGSLFSTR 91
            ::||.|:.|:...|.....|      ||||...||:|.||.:..:. .....:|..:||.:||.:
Mouse    17 VIFLILVDLMHRRQHWTSRY------PPGPVPWPVLGNLLQVDLDNIPYSLYKLQNRYGDVFSLQ 75

  Fly    92 LGSQLTVVMSDYKMIRECFRR--EEFTGRPDTPFMQTLNGYG------IINSTGKLWKDQRRFLH 148
            :..:..||::..|.::|....  ::....|..|..:.| |:.      ::.|.|..|::||:|..
Mouse    76 MAWKPVVVINGLKAMQEVLLTCGKDTADHPPVPIFEYL-GFKSKSQGVVLASYGPEWREQRQFSV 139

  Fly   149 DKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFS 213
            ..||.||:     ||:.:::.:..|.........|..||.::.:.:::.||.|||.||:.:.||.
Mouse   140 STLRNFGL-----GKKSLEEWVTKEAKHLCDAFTARAGQSINPNTMLNNAVCNVIASLIFARRFE 199

  Fly   214 IDDPKFRRFNFLIEEGMRLFGEIHTVDYIP-TMQCFP---SISTAKNKIAQNRAEMQRFYQDVID 274
            .:||...|...:.||.::     ....:|| .:..||   .|....:.:.|::........:::.
Mouse   200 YEDPFLIRMLKMREESLK-----EVTGFIPGVLNTFPILLRIPGLADMVFQSQKTFMAILDNLVT 259

  Fly   275 DHKRSFDPNN-IRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLL 338
            :::.::||:. .|:|.|.:|.||:|||  |.....|    ::|.|..|:.|||:|||.|..|||.
Mouse   260 ENRTTWDPDQPPRNLADAFLAEIQKAK--GNPESSF----NDENLCMVVSDLFTAGMVTTSTTLS 318

  Fly   339 WINVFMLRNPKEMR---------------RVQDELDQVVGRHRLPTIEDLQYLPITESTILESMR 388
            ...:.|:.:|...|               |||.|:|.|:|:.|.|.:.|...:|.|.:.|.|..|
Mouse   319 CALLLMILHPDVQREPGWGWEGGRGTIPSRVQQEIDAVIGQVRCPEMADQARMPYTNAVIHEVQR 383

  Fly   389 RSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKP 453
            ...|:||......:||:|:..:.||.|:.:||.::|:..|..:||||..|.|..|:|.:|...||
Mouse   384 FGDIIPLNIPRITSRDIEVQDFLIPKGTILIPNMSSMLKDETVWEKPLRFYPEHFLDAQGHFVKP 448

  Fly   454 EYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLK 518
            |.|:||..|||.|||:.||||||||||...:..|..::|.|||.||........:.|..::||..
Mouse   449 EAFMPFSAGRRSCLGEPLARMELFLFFTCLLQRFSFSVPAGQPQPSDHRIFAIPVAPYPYQVCAI 513

  Fly   519 RRPLG 523
            .|..|
Mouse   514 MREQG 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	143/457 (31%)
Cyp2d34	XP_030104365.1	CYP2D	68..509	CDD:410756	144/457 (32%)