DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2d34

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_030104365.1	Gene:	Cyp2d34 / 223706	MGIID:	2385022	Length:	519	Species:	Mus musculus

Alignment Length:	525	Identity:	164/525 - (31%)
Similarity:	260/525 - (49%)	Gaps:	52/525 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 MVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEK-HTRFMELAKQYGSLFSTR 91
            ::||.|:.|:...|.....|      ||||...||:|.||.:..:. .....:|..:||.:||.:
Mouse    17 VIFLILVDLMHRRQHWTSRY------PPGPVPWPVLGNLLQVDLDNIPYSLYKLQNRYGDVFSLQ 75

  Fly    92 LGSQLTVVMSDYKMIRECFRR--EEFTGRPDTPFMQTLNGYG------IINSTGKLWKDQRRFLH 148
            :..:..||::..|.::|....  ::....|..|..:.| |:.      ::.|.|..|::||:|..
Mouse    76 MAWKPVVVINGLKAMQEVLLTCGKDTADHPPVPIFEYL-GFKSKSQGVVLASYGPEWREQRQFSV 139

  Fly   149 DKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFS 213
            ..||.||:     ||:.:::.:..|.........|..||.::.:.:::.||.|||.||:.:.||.
Mouse   140 STLRNFGL-----GKKSLEEWVTKEAKHLCDAFTARAGQSINPNTMLNNAVCNVIASLIFARRFE 199

  Fly   214 IDDPKFRRFNFLIEEGMRLFGEIHTVDYIP-TMQCFP---SISTAKNKIAQNRAEMQRFYQDVID 274
            .:||...|...:.||.::     ....:|| .:..||   .|....:.:.|::........:::.
Mouse   200 YEDPFLIRMLKMREESLK-----EVTGFIPGVLNTFPILLRIPGLADMVFQSQKTFMAILDNLVT 259

  Fly   275 DHKRSFDPNN-IRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLL 338
            :::.::||:. .|:|.|.:|.||:|||  |.....|    ::|.|..|:.|||:|||.|..|||.
Mouse   260 ENRTTWDPDQPPRNLADAFLAEIQKAK--GNPESSF----NDENLCMVVSDLFTAGMVTTSTTLS 318

  Fly   339 WINVFMLRNPKEMR---------------RVQDELDQVVGRHRLPTIEDLQYLPITESTILESMR 388
            ...:.|:.:|...|               |||.|:|.|:|:.|.|.:.|...:|.|.:.|.|..|
Mouse   319 CALLLMILHPDVQREPGWGWEGGRGTIPSRVQQEIDAVIGQVRCPEMADQARMPYTNAVIHEVQR 383

  Fly   389 RSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKP 453
            ...|:||......:||:|:..:.||.|:.:||.::|:..|..:||||..|.|..|:|.:|...||
Mouse   384 FGDIIPLNIPRITSRDIEVQDFLIPKGTILIPNMSSMLKDETVWEKPLRFYPEHFLDAQGHFVKP 448

  Fly   454 EYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLK 518
            |.|:||..|||.|||:.||||||||||...:..|..::|.|||.||........:.|..::||..
Mouse   449 EAFMPFSAGRRSCLGEPLARMELFLFFTCLLQRFSFSVPAGQPQPSDHRIFAIPVAPYPYQVCAI 513

  Fly   519 RRPLG 523
            .|..|
Mouse   514 MREQG 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	155/491 (32%)
Cyp2d34	XP_030104365.1	p450	37..511	CDD:365848	154/490 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43796
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720