DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp-14A4

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_510207.1	Gene:	cyp-14A4 / 187573	WormBaseID:	WBGene00011009	Length:	491	Species:	Caenorhabditis elegans

Alignment Length:	508	Identity:	157/508 - (30%)
Similarity:	255/508 - (50%)	Gaps:	39/508 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYL-LFMGSEKHTRFMELAKQYGSLFS 89
            |::.|     .|..:.:||..|.::||.|.||:.|||||.| ...|......|.||||.||..::
Worm     5 LILAF-----FVATVGYLVHFYLKVRKYPKGPFPLPVIGNLHQIPGGNLEIWFDELAKIYGPCYT 64

  Fly    90 TRLGSQL-TVVMSDYKMIRECF-RREEFTGR---PDTPFMQTLNGYGIINSTGKLWKDQRRFLHD 149
              :.|.| .||::|:..|:..| .:.||..|   |....:...:..||:||:|:.|:.|||....
Worm    65 --VWSPLPCVVLTDFDHIKNAFVTQGEFNNRAHKPPESLLHVHDNTGILNSSGENWQLQRRTSLK 127

  Fly   150 KLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDG-QPVDMSPVISVAVSNVICSLMMSTRFS 213
            .||.|||     ||..|:::|:..|.|.:..|..:|. :..|:...:.:.|.|||..::....|.
Worm   128 ILRDFGM-----GKNLMEEQIVKSVQEMMTQLEKTDDKKKADIFWPVQLCVGNVINQVLFGYHFK 187

  Fly   214 IDD-PKFRRFNFLIEEGMR-LFGEIH-TVDYIPTMQCFPSIST-AKNKIAQNRAEMQRFYQDVID 274
            .|| .:|::|..:|:..:| |.|:.. .|...|.::..|.|.. ...:|.:|....|.|.::.:.
Worm   188 YDDCERFQKFVSVIDFHLRTLLGKCSLLVSAFPMLRHVPIIGEYGYQRIKRNIKSYQYFIEEEVA 252

  Fly   275 DHKRSF-DPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLL 338
            ...:|| :.|...:.|..|:.::::....|.|.     ||    |....:|.:.|||||...:|.
Worm   253 TQMKSFEEENEPENFVHAYMQQMKQNGHPGLDV-----KN----LRACALDFWLAGMETTSNSLR 308

  Fly   339 WINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTR 403
            |...:|:::|....:|:.|:..|||..|.|::.|...:|.|::.|.|..|.|::||...||...:
Worm   309 WHIAYMMKHPDIQDKVRKEILDVVGNSRFPSMSDKPNMPYTQAVIHEVQRHSNMVPFLGTHQSNK 373

  Fly   404 DVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKP---EYFIPFGVGRRM 465
            |..:.|..||||::|:....||..:..::.....|.|.|::..:||....   |..|||.||:|.
Worm   374 DTNVLGQNIPAGTNVLVQAWSVMRNDPIFINQLSFNPDRYLMADGKSFDKNILEKTIPFSVGKRS 438

  Fly   466 CLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLK 518
            |:|:.||||||||.|::.:..::. :..| |: .:..:.||.:|.:.:...||
Worm   439 CIGEGLARMELFLIFSALIQKYEF-IANG-PV-DMSYDFGAVLTIKPYTCQLK 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	147/477 (31%)
cyp-14A4	NP_510207.1	p450	28..483	CDD:278495	147/473 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720