DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2d4

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_612524.1	Gene:	Cyp2d4 / 171522	RGDID:	620640	Length:	500	Species:	Rattus norvegicus

Alignment Length:	501	Identity:	172/501 - (34%)
Similarity:	255/501 - (50%)	Gaps:	34/501 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEK-HTRFMELAKQYGSLFSTRLGSQLT 97
            |.||.|:.   |..|...:.||||...||:|.||.:..:. ...|.:|..::|.|||.:|..:..
  Rat    20 LLLVDLMH---RRQRWTSRYPPGPVPWPVLGNLLQIDFQNMPAGFQKLRCRFGDLFSLQLAFESV 81

  Fly    98 VVMSDYKMIRECFRR--EEFTGRPDTPFMQTLNGYG------IINSTGKLWKDQRRFLHDKLRQF 154
            ||::....:||...:  |:...||...| ...:|:|      ::...|..|:.||||.....|.|
  Rat    82 VVLNGLPALREALVKYSEDTADRPPLHF-NDQSGFGPRSQGVVLARYGPAWRQQRRFSVSTFRHF 145

  Fly   155 GMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKF 219
            |:     ||:.:::.:..|............|.|...:.::..||.|||.||:.:.||..:||:|
  Rat   146 GL-----GKKSLEQWVTEEARCLCAAFADHSGFPFSPNTLLDKAVCNVIASLLFACRFEYNDPRF 205

  Fly   220 RRFNFLIEEGMRLFGEIHTVDYIP-TMQCFP---SISTAKNKIAQNRAEMQRFYQDVIDDHKRSF 280
            .|...|:::.:.     ....::| .:..||   .|.....|:...:........:::.:||.::
  Rat   206 IRLLDLLKDTLE-----EESGFLPMLLNVFPMLLHIPGLLGKVFSGKKAFVAMLDELLTEHKVTW 265

  Fly   281 DP-NNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFM 344
            || ...|||.|.:|.|:||||  |.....|    ::|.|..|:.|||.|||.|..|||.|..:||
  Rat   266 DPAQPPRDLTDAFLAEVEKAK--GNPESSF----NDENLRVVVADLFMAGMVTTSTTLTWALLFM 324

  Fly   345 LRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNG 409
            :..|....|||.|:|:|:|:.|.|.:.|...:|.|.:.|.|..|.:.|:||...|..:||:|:.|
  Rat   325 ILRPDVQCRVQQEIDEVIGQVRRPEMADQARMPFTNAVIHEVQRFADILPLGVPHKTSRDIEVQG 389

  Fly   410 YTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLARM 474
            :.||.|:.:|..::||..|..:||||..|.|..|:|.:|...|.|.|:||..|||.|||:.||||
  Rat   390 FLIPKGTTLIINLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSAGRRACLGEPLARM 454

  Fly   475 ELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRR 520
            ||||||...:..|..::|.|||.||..|..||..||..:::|...|
  Rat   455 ELFLFFTCLLQRFSFSVPAGQPRPSNYGVFGALTTPRPYQLCASPR 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	164/476 (34%)
Cyp2d4	NP_612524.1	p450	37..496	CDD:278495	164/475 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45879
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720