Protein Alignment Cyp18a1 and Cyp2c22

DIOPT Version :9

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_612521.2
• Gene: Cyp2c22 / 171518
• RGDID: 620368
• Length: 489
• Species: Rattus norvegicus
• Alignment Length: 520
• Identity: 169/520 - (32%)
• Similarity: 266/520 - (51%)
• Gaps: 67/520 - (12%)

  Fly    27 LMVFLG--LLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTRFM-ELAKQYGSLF 88
            |.:|||  |..||.|..|...:.|  |||||||..||:.|.:|.:|.:..::.| .|||:||.:|
  Rat     3 LFIFLGIWLSCLVFLFLWNQHHVR--RKLPPGPTPLPIFGNILQVGVKNISKSMCMLAKEYGPVF 65

  Fly    89 STRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTLN-GYGIINSTGKLWKDQRRFLHDK 150
            :..||.:.|||:..|::::|..  |.|||:.:..:..:..:: |.||:.|.|::||..|||....
  Rat    66 TMYLGMKPTVVLYGYEVLKEALIDRGEEFSDKMHSSMLSKVSQGLGIVFSNGEIWKQTRRFSLMV 130

  Fly   151 LRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSID 215
            ||..||     ||:.::.||..||...:..|..::|.|.|.|.:::....|||.|::...||...
  Rat   131 LRSMGM-----GKRTIENRIQEEVVYLLEALRKTNGSPCDPSFLLACVPCNVISSVIFQHRFDYS 190

  Fly   216 DPKFRRF--NF------LIEEGMRLFGEIHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDV 272
            |.||::|  ||      |.....:|......:.|:|.:.         ||..::..|.::|....
  Rat   191 DEKFQKFIENFHTKIEILASPWAQLCSAYPVLYYLPGIH---------NKFLKDVTEQKKFILME 246

  Fly   273 IDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQ-------LVQVIIDLFSAGM 330
            |:.|:.|.:.:|.:|.:|::|.::||.|             |.|:       |:..|.|||.||.
  Rat   247 INRHRASLNLSNPQDFIDYFLIKMEKEK-------------HNEKSEFTMDNLIVTIGDLFGAGT 298

  Fly   331 ETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPL 395
            ||..:|:.:..:.:|:.|:...::|:|:.:|:||||.|.::|..::|.|::.:.|..|....||:
  Rat   299 ETTSSTIKYGLLLLLKYPEVTAKIQEEITRVIGRHRRPCMQDRNHMPYTDAVLHEIQRYIDFVPI 363

  Fly   396 ATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFG 460
            ......|:|||..||.||.|:.|:..:.|...|...:..||:|.|..|:|.:|..:|.:||:.|.
  Rat   364 PLPRKTTQDVEFRGYHIPKGTSVMACLTSALHDDKEFPNPEKFDPGHFLDEKGNFKKSDYFMAFS 428

  Fly   461 VGRRMCLGDVLARMELFLFFASFMHCF---------DIALPEGQPLPSLKGNVGATITPESFKVC 516
            .|||.|:|:.|||||:||...|.:..|         ||.....||        |....|..|::|
  Rat   429 AGRRACIGEGLARMEMFLILTSILQHFTLKPLVNPEDIDTTPVQP--------GLLSVPPPFELC 485

  Fly   517  516
              Rat   486  485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	156/491 (32%)
Cyp2c22	NP_612521.2	CYP2C-like	61..484	CDD:410758	142/457 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820