DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2t1

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_599196.2	Gene:	Cyp2t1 / 171380	RGDID:	620086	Length:	497	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	173/515 - (33%)
Similarity:	267/515 - (51%)	Gaps:	54/515 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LLALVTLL----QWLVRNYR-ELRK-LPPGPWGLPVIGYLLFMGSEKHTR-FMELAKQYGSLFST 90
            ||.::||:    .||....| .::| |||||..||::|.||.:.|....| .|||:.::|.:|:.
  Rat    10 LLLILTLMLMSWGWLAHQARARMQKDLPPGPAPLPLLGNLLQLQSGHLDRVLMELSSRWGPVFTV 74

  Fly    91 RLGSQLTVVMSDYKMIREC--FRREEFTGRPD-TPFMQTLNGYGIINSTGKLWKDQRRFLHDKLR 152
            .||.:..||:|.|..:|:.  .:.:.|:||.. ..|.:..:|.||:.|.|..|:..|.|....|:
  Rat    75 WLGPRPAVVLSGYAALRDALVLQADAFSGRGSMAVFERFTHGNGIVFSNGPRWRTLRNFALGALK 139

  Fly   153 QFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDP 217
            :||:     |...:::||:.|....:....|:.|.|.|...::..|||||||:::...|::..||
  Rat   140 EFGV-----GTSTIEERILEETACVLDEFQATMGAPFDPRRLLDNAVSNVICTVVFGKRYNYGDP 199

  Fly   218 KFRRFNFLIEEGMRL----FGEIHTVDYIPTMQCFPS----ISTAKNKIAQNRAEMQRFYQDVID 274
            :|.|...|..:..|:    :||        |...|||    |....::|.:|..|::.|..:.|.
  Rat   200 EFLRLLDLFSDNFRIMSSRWGE--------TYNMFPSFMDWIPGPHHRIFKNFQELRLFISEQIQ 256

  Fly   275 DHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNH--EEQLVQVIIDLFSAGMETIKTTL 337
            .|::|......||.:|.:|        |..|.|..|.::|  :|.||....:||..|.||..|||
  Rat   257 WHRQSRQTGEPRDFIDCFL--------EQMDKEHQDPESHFQDETLVMTTHNLFFGGTETTSTTL 313

  Fly   338 LWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPT 402
            .:..:.||:.|:...:||:|||..|||.|.|::.|..:||.|.:.:.|..|..|::||....:..
  Rat   314 RYGLLIMLKYPEVAAKVQEELDATVGRTRAPSLADRAHLPYTNAVLHEIQRFISVLPLGLPRALI 378

  Fly   403 RDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCL 467
            |||.|..:.:..|:.||||:.|.|.||..::.|:.|.|:.|:|.:|:.:..:.|:||..|:||||
  Rat   379 RDVNLRNHFLHKGTFVIPLLVSAHRDPTQFKDPDHFNPTNFLDDQGEFQNNDAFMPFAPGKRMCL 443

  Fly   468 GDVLARMELFLFFASFMHCFDIALPEGQP-----LPSLK--GNVGATITPESFKVCLKRR 520
            |..|||.|:|||..:.:..|.: ||.|.|     .|...  |||     |.:|::.|..|
  Rat   444 GAGLARSEIFLFLTAILQKFSL-LPVGSPADIDLTPQCTGLGNV-----PPAFQLRLVAR 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	162/483 (34%)
Cyp2t1	NP_599196.2	cytochrome_P450	68..492	CDD:425388	148/450 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010