Protein Alignment Cyp18a1 and CYP21A2

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_000491.4
• Gene: CYP21A2 / 1589
• HGNCID: 2600
• Length: 495
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 158/525 - (30%)
• Similarity: 251/525 - (47%)
• Gaps: 67/525 - (12%)

  Fly    28 MVFLGLLALVTLLQW--LVRNYRELRK--LPP-GPWGLPVIGYLLFMGSEKHTRFMELAKQYGSL 87
            |:.||||.|:.||..  |:.|:.:||.  ||| .|      |:|..:..:.....:.|.:::|.:
Human     1 MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAP------GFLHLLQPDLPIYLLGLTQKFGPI 59

  Fly    88 FSTRLGSQLTVVMSDYKMIRECFRRE--EFTGRPDT----------PFMQTLNGYGIINSTGKLW 140
            :...||.|..||::..:.|.|...::  :|.|||:.          |.: :|..|.:      ||
Human    60 YRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDL-SLGDYSL------LW 117

  Fly   141 KDQRRFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICS 205
            |     .|.||.:..: .:|. :..|:..:.....||...:.|..|.||.:....|:...::||.
Human   118 K-----AHKKLTRSAL-LLGI-RDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICY 175

  Fly   206 LMMSTRFSIDDPKFRRFNFLIEEGMRLFG--EIHTVDYIPTMQCFPSISTAKNKIAQNR----AE 264
            |....:.. ||.....:...|:|.::.:.  .|..||.||.::.||:....:.|.|..:    .|
Human   176 LTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVE 239

  Fly   265 MQRFYQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAG 329
            ||      :..||.|......||::|:.|..:.:...|....:|.:|..|     ...:||...|
Human   240 MQ------LRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVH-----MAAVDLLIGG 293

  Fly   330 METIKTTLLWINVFMLRNPKEMRRVQDELDQVVG----RHRLPTIEDLQYLPITESTILESMRRS 390
            .||...||.|..||:|.:|:..:|:|:|||..:|    ..|:| .:|...||:..:||.|.:|..
Human   294 TETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPLLNATIAEVLRLR 357

  Fly   391 SIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEY 455
            .:||||..|..||...::||.||.|:.:||.:...|:|..:||:|.||.|.||:: .||..:.
Human   358 PVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE-PGKNSRA-- 419

  Fly   456 FIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLK--GNVGATITPESFKVCLK 518
             :.||.|.|:|||:.|||:|||:.....:..|.: ||.|..||||:  .:....:..:.|:|.|:
Human   420 -LAFGCGARVCLGEPLARLELFVVLTRLLQAFTL-LPSGDALPSLQPLPHCSVILKMQPFQVRLQ 482

  Fly   519 RRPLG 523
            .|.:|
Human   483 PRGMG 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	135/453 (30%)
CYP21A2	NP_000491.4	CYP21	56..482	CDD:410767	136/457 (30%)