Protein Alignment Cyp18a1 and CYP17A1

DIOPT Version :9

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_000093.1
• Gene: CYP17A1 / 1586
• HGNCID: 2593
• Length: 508
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 154/520 - (29%)
• Similarity: 260/520 - (50%)
• Gaps: 54/520 - (10%)

  Fly    28 MVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFM--GSEKHTRFMELAKQYGSLFST 90
            :|.|.||.|..|. |..|.... .|.|.....||::|.|.|:  ....|..|.:|.|:||.::|.
Human     4 LVALLLLTLAYLF-WPKRRCPG-AKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSV 66

  Fly    91 RLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTL-----NGYGI-INSTGKLWKDQRRFL 147
            |:|::.||::..:::.:|..  :.::|:|||.   |.||     |..|| ...:|..|:     |
Human    67 RMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQ---MATLDIASNNRKGIAFADSGAHWQ-----L 123

  Fly   148 HDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRF 212
            |.:|.........:|.|:::|.|..|:......|...:||.:|:|..:.|||:|||..:..:|.:
Human   124 HRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSY 188

  Fly   213 SIDDPK---FRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQD--- 271
            ...||:   .:.:|..|.:.:   .:...||.:|.::.||      ||..:......:...|
Human   189 KNGDPELNVIQNYNEGIIDNL---SKDSLVDLVPWLKIFP------NKTLEKLKSHVKIRNDLLN 244

  Fly   272 -VIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEG--------TDAELFDGKNHEEQLVQVIIDLFS 327
             :::::|..|..::|.:::|    .:.:||...        .|:||. ..||   ::..|.|:|.
Human   245 KILENYKEKFRSDSITNMLD----TLMQAKMNSDNGNAGPDQDSELL-SDNH---ILTTIGDIFG 301

  Fly   328 AGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSI 392
            ||:||..:.:.|...|:|.||:..:::.:|:||.||..|.|||.|...|.:.|:||.|.:|...:
Human   302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPV 366

  Fly   393 VPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEG-KVRKPEY- 455
            .|:...|....|..:..:.:..|:.||..:.::|.:...|.:|::|.|.||::..| ::..|..
Human   367 APMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVS 431

  Fly   456 FIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRR 520
            ::|||.|.|.|:|::|||.||||..|..:..||:.:|:...||||:|........:||||.:|.|
Human   432 YLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVR 496

  Fly   521  520
            Human   497  496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	143/489 (29%)
CYP17A1	NP_000093.1	p450	28..493	CDD:306555	143/489 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910