Protein Alignment Cyp18a1 and CYP2J2

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_000766.2
• Gene: CYP2J2 / 1573
• HGNCID: 2634
• Length: 502
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 169/503 - (33%)
• Similarity: 259/503 - (51%)
• Gaps: 33/503 - (6%)

  Fly    25 HLLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIG-YLLFMGSEKHTRFMELAKQYGSLF 88
            |...:.||.:|.:....:|.|  |..:..|||||.||.:| :.|....:.|.......|:||:||
Human    17 HPRTLLLGTVAFLLAADFLKR--RRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLF 79

  Fly    89 STRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTL-NGYGIINSTGKLWKDQRRFLHDK 150
            |..||....|:::...:|:|..  ..:.|..||.||..:.: ...|:|.|:|:.||:||||....
Human    80 SLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTA 144

  Fly   151 LRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSID 215
            ||.||:     ||:.:::||..|.......:...:|||.|....|:.||||:|||:....||...
Human   145 LRNFGL-----GKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQ 204

  Fly   216 DPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQ---CFPSIST----AKNKIAQNRAEMQRFYQDVI 273
            |..|::.       ::|..|:..::...|.|   .||.|..    ....:..|..:::.|...:|
Human   205 DSWFQQL-------LKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMI 262

  Fly   274 DDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLL 338
            |.|::.::|...||.:|.||.|:.|.....|.:      .|||.|:...:|||.||.||..|||.
Human   263 DKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSS------FHEENLICSTLDLFFAGTETTSTTLR 321

  Fly   339 WINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTR 403
            |..::|...|:...:||.|:|:|:|:.:.|:....:.:|.|.:.|.|..|..:|:||......|.
Human   322 WALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTV 386

  Fly   404 DVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLG 468
            |..|.||.:|.|:.::..:.::|.||..|..|:.|.|..|:: .|:.:|.|.|:||.:|:|.|||
Human   387 DTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLE-NGQFKKREAFMPFSIGKRACLG 450

  Fly   469 DVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVC 516
            :.|||.|||:||.|.|..|....|..:.| |||..:|.||:|.|.::|
Human   451 EQLARTELFIFFTSLMQKFTFRPPNNEKL-SLKFRMGITISPVSHRLC 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	149/439 (34%)
CYP2J2	NP_000766.2	CYP2J	75..496	CDD:410755	150/440 (34%)