DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and CYP2F1

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_016881873.1	Gene:	CYP2F1 / 1572	HGNCID:	2632	Length:	573	Species:	Homo sapiens

Alignment Length:	453	Identity:	156/453 - (34%)
Similarity:	244/453 - (53%)	Gaps:	35/453 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 VFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKH-TRFMELAKQYGSLFSTRL 92
            :.|.|||||.||  |..:.|:..||||||..|.::|.||.:.|:.. |...:|:|:|||:::..|
Human    83 ILLLLLALVCLL--LTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGSMYTVHL 145

  Fly    93 GSQLTVVMSDYKMIRECF--RREEFTGRPDTP-FMQTLNGYGIINSTGKLWKDQRRFLHDKLRQF 154
            |.:..||:|.|:.::|..  :.|||:||.|.| |.....|.||..|:|..||..|:|....||.|
Human   146 GPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLRQFSIQILRNF 210

  Fly   155 GMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKF 219
            ||     ||:.:::||:.|....:..|..::|:|.|.:.|:|.:|||:|||::..:||..||.:.
Human   211 GM-----GKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERL 270

  Fly   220 RRFNFLIEEGMRL----FGEIHTVDYIPTMQCFPS----ISTAKNKIAQNRAEMQRFYQDVIDDH 276
            .....||.:..::    :||::.:        |||    :.....:|.||...::......:.||
Human   271 LTIIRLINDNFQIMSSPWGELYDI--------FPSLLDWVPGPHQRIFQNFKCLRDLIAHSVHDH 327

  Fly   277 KRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWIN 341
            :.|.||.:.||.:..:|.::.:.|.:..      ...|.:.|:....:|...|.:|:.|||....
Human   328 QASLDPRSPRDFIQCFLTKMAEEKEDPL------SHFHMDTLLMTTHNLLFGGTKTVSTTLHHAF 386

  Fly   342 VFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVE 406
            :.:::.||...|||:|:|.||||.|||.::|...:|.|::.|.|..|.:.|:|:...|..|||..
Human   387 LALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTA 451

  Fly   407 LNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPF--GVGRRMCL 467
            ..|:.||.|:.||.|:|:||.||:.:..|:||.|..|:|.....:|...|:||  |.||...|
Human   452 FRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAFMPFSAGEGRNQSL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	144/428 (34%)
CYP2F1	XP_016881873.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820