Protein Alignment Cyp18a1 and CYP2E1

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_000764.1
• Gene: CYP2E1 / 1571
• HGNCID: 2631
• Length: 493
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 172/511 - (33%)
• Similarity: 264/511 - (51%)
• Gaps: 43/511 - (8%)

  Fly    28 MVFLGLLALVTLLQW-----LVRNYRELR---KLPPGPWGLPVIGYLLFMGSEKHTR-FMELAKQ 83
            |..||:  .|.||.|     ||..:|::.   .|||||:.||:||.|..:..:...: |..||::
Human     1 MSALGV--TVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQR 63

  Fly    84 YGSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTLNGYGIINSTGKLWKDQRRF 146
            :|.:|:..:|||..|||..||.::|..  .::||:||.|.|........|||.:.|..|||.|||
Human    64 FGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRF 128

  Fly   147 LHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTR 211
            ....||.:||     |||..:.||..|.|..:..|..:.|||.|.:.:|..|..|||..::....
Human   129 SLTTLRNYGM-----GKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKH 188

  Fly   212 FSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPS----ISTAKNKIAQNRAEMQRFYQDV 272
            |..:|.||.|..:|..|...|.    :..::.....|||    :..:..|:.:|.||::.:..:.
Human   189 FDYNDEKFLRLMYLFNENFHLL----STPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSER 249

  Fly   273 IDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTL 337
            :.:|.:|.|||..|||.|..|.|:||.|.........||      :...:.|||.||.||..|||
Human   250 VKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDG------ITVTVADLFFAGTETTSTTL 308

  Fly   338 LWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPT 402
            .:..:.:::.|:...::.:|:|:|:|..|:|.|:|.|.:|..::.:.|..|..::||....|..|
Human   309 RYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEAT 373

  Fly   403 RDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCL 467
            ||....||.||.|:.|:|.::||..|...:..||:|:|..|::..||.:..:||.||..|:|:|.
Human   374 RDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCA 438

  Fly   468 GDVLARMELFLFFASFMHCFDIALPEGQPLPSLKG------NVGATITPESFKVCL 517
            |:.||||||||...:.:..|::     :||...|.      ::|....|..:|:|:
Human   439 GEGLARMELFLLLCAILQHFNL-----KPLVDPKDIDLSPIHIGFGCIPPRYKLCV 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	147/441 (33%)
CYP2E1	NP_000764.1	CYP2C-like	64..487	CDD:410758	147/442 (33%)