DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp18a1 and CYP2E1

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_000764.1	Gene:	CYP2E1 / 1571	HGNCID:	2631	Length:	493	Species:	Homo sapiens

Alignment Length:	511	Identity:	172/511 - (33%)
Similarity:	264/511 - (51%)	Gaps:	43/511 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 MVFLGLLALVTLLQW-----LVRNYRELR---KLPPGPWGLPVIGYLLFMGSEKHTR-FMELAKQ 83
            |..||:  .|.||.|     ||..:|::.   .|||||:.||:||.|..:..:...: |..||::
Human     1 MSALGV--TVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQR 63

  Fly    84 YGSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTLNGYGIINSTGKLWKDQRRF 146
            :|.:|:..:|||..|||..||.::|..  .::||:||.|.|........|||.:.|..|||.|||
Human    64 FGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRF 128

  Fly   147 LHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTR 211
            ....||.:||     |||..:.||..|.|..:..|..:.|||.|.:.:|..|..|||..::....
Human   129 SLTTLRNYGM-----GKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKH 188

  Fly   212 FSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPS----ISTAKNKIAQNRAEMQRFYQDV 272
            |..:|.||.|..:|..|...|.    :..::.....|||    :..:..|:.:|.||::.:..:.
Human   189 FDYNDEKFLRLMYLFNENFHLL----STPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSER 249

  Fly   273 IDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTL 337
            :.:|.:|.|||..|||.|..|.|:||.|.........||      :...:.|||.||.||..|||
Human   250 VKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDG------ITVTVADLFFAGTETTSTTL 308

  Fly   338 LWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPT 402
            .:..:.:::.|:...::.:|:|:|:|..|:|.|:|.|.:|..::.:.|..|..::||....|..|
Human   309 RYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEAT 373

  Fly   403 RDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCL 467
            ||....||.||.|:.|:|.::||..|...:..||:|:|..|::..||.:..:||.||..|:|:|.
Human   374 RDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCA 438

  Fly   468 GDVLARMELFLFFASFMHCFDIALPEGQPLPSLKG------NVGATITPESFKVCL 517
            |:.||||||||...:.:..|::     :||...|.      ::|....|..:|:|:
Human   439 GEGLARMELFLLLCAILQHFNL-----KPLVDPKDIDLSPIHIGFGCIPPRYKLCV 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	160/475 (34%)
CYP2E1	NP_000764.1	p450	33..489	CDD:365848	160/475 (34%)
CYP2E1	NP_000764.1	Substrate binding. /evidence=ECO:0000305	298..303		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920