Protein Alignment Cyp18a1 and CYP2D6

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_000097.3
• Gene: CYP2D6 / 1565
• HGNCID: 2625
• Length: 497
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 179/514 - (34%)
• Similarity: 269/514 - (52%)
• Gaps: 49/514 - (9%)

  Fly    31 LGLLALV----------TLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTR-FMELAKQY 84
            :||.|||          .|:..:.|..|...:.||||..||.:|.||.:..:.... |.:|.:::
Human     1 MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRF 65

  Fly    85 GSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTLNGYG------IINSTGKLWK 141
            |.:||.:|.....||::....:||..  ..|:...||..|..|.| |:|      .:...|..|:
Human    66 GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQIL-GFGPRSQGVFLARYGPAWR 129

  Fly   142 DQRRFLHDKLRQFGMTYMGNGKQQMQKRIMTEV----HEFIGHLHASDGQPVDMSPVISVAVSNV 202
            :||||....||..|:     ||:.:::.:..|.    ..|..|    .|:|...:.::..|||||
Human   130 EQRRFSVSTLRNLGL-----GKKSLEQWVTEEAACLCAAFANH----SGRPFRPNGLLDKAVSNV 185

  Fly   203 ICSLMMSTRFSIDDPKFRRFNFLIEEGMR----LFGEIHTVDYIPTMQCFPSISTAKNKIAQNRA 263
            |.||....||..|||:|.|...|.:||::    ...|:  ::.:|.:...|:::   .|:.:.:.
Human   186 IASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREV--LNAVPVLLHIPALA---GKVLRFQK 245

  Fly   264 EMQRFYQDVIDDHKRSFDP-NNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFS 327
            .......:::.:|:.::|| ...|||.:.:|.|:||||  |.....|    ::|.|..|:.||||
Human   246 AFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAK--GNPESSF----NDENLRIVVADLFS 304

  Fly   328 AGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSI 392
            |||.|..|||.|..:.|:.:|...||||.|:|.|:|:.|.|.:.|..::|.|.:.|.|..|...|
Human   305 AGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDI 369

  Fly   393 VPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFI 457
            |||..||..:||:|:.|:.||.|:.:|..::||..|..:||||..|.|..|:|.:|...|||.|:
Human   370 VPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFL 434

  Fly   458 PFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVC 516
            ||..|||.|||:.||||||||||.|.:..|..::|.|||.||..|.....::|..:::|
Human   435 PFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELC 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	159/446 (36%)
CYP2D6	NP_000097.3	CYP2D	65..492	CDD:410756	159/447 (36%)