Protein Alignment Cyp18a1 and CYP2C18

DIOPT Version :9

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_000763.1
• Gene: CYP2C18 / 1562
• HGNCID: 2620
• Length: 490
• Species: Homo sapiens
• Alignment Length: 518
• Identity: 167/518 - (32%)
• Similarity: 266/518 - (51%)
• Gaps: 66/518 - (12%)

  Fly    27 LMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMG----SEKHTRFMELAKQYGSL 87
            |::.|..|.|::|  |  |......:||.||..||:||.:|.:.    |:..|.|   :|.||.:
Human     7 LVLCLSCLFLLSL--W--RQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNF---SKVYGPV 64

  Fly    88 FSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTLN-GYGIINSTGKLWKDQRRFLHD 149
            |:...|.:..||:..|:.::|..  ..|||:||...|..:.:| |.||:.|.||.||:.|||...
Human    65 FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLM 129

  Fly   150 KLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSI 214
            .||.|||     ||:.::.|:..|....:..|..::..|.|.:.::..|..|||||::...||..
Human   130 TLRNFGM-----GKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDY 189

  Fly   215 DDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPS----ISTAKNKIAQNRAEMQRFYQDVIDD 275
            .|.:|........|.:|:...    .:|.....||:    :..:.||||:|.|.::.:..:.|.:
Human   190 KDQRFLNLMEKFNENLRILSS----PWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKE 250

  Fly   276 HKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQ-------LVQVIIDLFSAGMETI 333
            |:.|.|.|:.||.:|.:|.::|:.|             |.:|       |:..:.|:|.||.||.
Human   251 HQESLDMNSARDFIDCFLIKMEQEK-------------HNQQSEFTVESLIATVTDMFGAGTETT 302

  Fly   334 KTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATT 398
            .|||.:..:.:|:.|:...:||:|::.||||:|.|.::|..::|.|::.:.|..|...::|....
Human   303 STTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLP 367

  Fly   399 HSPTRDVELNGYTIPAGSHVIPLINSV-HMD---PNLWEKPEEFRPSRFIDTEGKVRKPEYFIPF 459
            |:.|.||:...|.||.|:.:|..:.|| |.|   ||    ||.|.|..|:|..|..:|.:||:||
Human   368 HAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPN----PEMFDPGHFLDKSGNFKKSDYFMPF 428

  Fly   460 GVGRRMCLGDVLARMELFLFFASFMHCFDIAL---PEG---QPLPSLKGNVGATITPESFKVC 516
            ..|:|||:|:.|||||||||..:.:..|::..   |:.   .|:.:..|.|     |..:::|
Human   429 SAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRV-----PPLYQLC 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	159/491 (32%)
CYP2C18	NP_000763.1	p450	30..487	CDD:306555	159/491 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820