Protein Alignment Cyp18a1 and CYP2C9

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_000762.2
• Gene: CYP2C9 / 1559
• HGNCID: 2623
• Length: 490
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 163/511 - (31%)
• Similarity: 267/511 - (52%)
• Gaps: 48/511 - (9%)

  Fly    26 LLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTRFM-ELAKQYGSLFS 89
            |:::.|.|..|:.|..|  |......||||||..|||||.:|.:|.:..::.: .|:|.||.:|:
Human     4 LVVLVLCLSCLLLLSLW--RQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFT 66

  Fly    90 TRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTLN-GYGIINSTGKLWKDQRRFLHDKL 151
            ...|.:..||:..|:.::|..  ..|||:||...|..:..| |:||:.|.||.||:.|||....|
Human    67 LYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTL 131

  Fly   152 RQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDD 216
            |.|||     ||:.::.|:..|....:..|..:...|.|.:.::..|..|||||::...||...|
Human   132 RNFGM-----GKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKD 191

  Fly   217 PKFRRFNFLIEEGMRL-----------FGEIHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQ 270
            .:|......:.|.:::           |..|  :||.|         ...||:.:|.|.|:.:..
Human   192 QQFLNLMEKLNENIKILSSPWIQICNNFSPI--IDYFP---------GTHNKLLKNVAFMKSYIL 245

  Fly   271 DVIDDHKRSFDPNNIRDLVDFYLCEIEKAK----AEGTDAELFDGKNHEEQLVQVIIDLFSAGME 331
            :.:.:|:.|.|.||.:|.:|.:|.::||.|    :|.|          .|.|....:|||.||.|
Human   246 EKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFT----------IESLENTAVDLFGAGTE 300

  Fly   332 TIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLA 396
            |..|||.:..:.:|::|:...:||:|:::|:||:|.|.::|..::|.|::.:.|..|...::|.:
Human   301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTS 365

  Fly   397 TTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGV 461
            ..|:.|.|::...|.||.|:.::..:.||..|...:..||.|.|..|:|..|..:|.:||:||..
Human   366 LPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSA 430

  Fly   462 GRRMCLGDVLARMELFLFFASFMHCFDI-ALPEGQPLPSLKGNVGATITPESFKVC 516
            |:|:|:|:.||.||||||..|.:..|:: :|.:.:.|.:.....|....|..:::|
Human   431 GKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLC 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	139/448 (31%)
CYP2C9	NP_000762.2	CYP2C-like	61..485	CDD:410758	140/449 (31%)