Protein Alignment Cyp18a1 and CYP2C8

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_000761.3
• Gene: CYP2C8 / 1558
• HGNCID: 2622
• Length: 490
• Species: Homo sapiens
• Alignment Length: 506
• Identity: 171/506 - (33%)
• Similarity: 268/506 - (52%)
• Gaps: 40/506 - (7%)

  Fly    26 LLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTR-FMELAKQYGSLFS 89
            :|::.|..:.|.:|  |  |.....|||||||..||:||.:|.:..:...: |...:|.||.:|:
Human     6 VLVLCLSFMLLFSL--W--RQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFT 66

  Fly    90 TRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTL-NGYGIINSTGKLWKDQRRFLHDKL 151
            ...|....||...|:.::|..  ..|||:||.::|..|.: .|.|||:|.||.||:.|||....|
Human    67 VYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTL 131

  Fly   152 RQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDD 216
            |.|||     ||:.::.|:..|.|..:..|..:...|.|.:.::..|..|||||::...||...|
Human   132 RNFGM-----GKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKD 191

  Fly   217 PKF----RRFNFLIEEGMRLFGE--IHTVDYIPTM-QCFPSISTAKNKIAQNRAEMQRFYQDVID 274
            ..|    :|||    |..|:...  |...:..|.: .|||.   ..||:.:|.|..:.:.::.:.
Human   192 QNFLTLMKRFN----ENFRILNSPWIQVCNNFPLLIDCFPG---THNKVLKNVALTRSYIREKVK 249

  Fly   275 DHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHE---EQLVQVIIDLFSAGMETIKTT 336
            :|:.|.|.||.||.:|.:|.::|:.|         |.:..|   |.||..:.|||.||.||..||
Human   250 EHQASLDVNNPRDFIDCFLIKMEQEK---------DNQKSEFNIENLVGTVADLFVAGTETTSTT 305

  Fly   337 LLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSP 401
            |.:..:.:|::|:...:||:|:|.|:||||.|.::|..::|.|::.:.|..|.|.:||....|:.
Human   306 LRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAV 370

  Fly   402 TRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMC 466
            |.|.:...|.||.|:.::.|:.||..|...:..|..|.|..|:|..|..:|.:||:||..|:|:|
Human   371 TTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRIC 435

  Fly   467 LGDVLARMELFLFFASFMHCFDI-ALPEGQPLPSLKGNVGATITPESFKVC 516
            .|:.|||||||||..:.:..|:: ::.:.:.|.:.....|....|.|:::|
Human   436 AGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQIC 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	149/443 (34%)
CYP2C8	NP_000761.3	CYP2C-like	61..485	CDD:410758	150/444 (34%)