DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and CYP2C19

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_000760.1	Gene:	CYP2C19 / 1557	HGNCID:	2621	Length:	490	Species:	Homo sapiens

Alignment Length:	504	Identity:	163/504 - (32%)
Similarity:	266/504 - (52%)	Gaps:	36/504 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTRFM-ELAKQYGSLFS 89
            :|::.|..|.|:::  |  |......||||||..|||||.:|.:..:..::.: .|:|.||.:|:
Human     6 VLVLCLSCLLLLSI--W--RQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFT 66

  Fly    90 TRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTLN-GYGIINSTGKLWKDQRRFLHDKL 151
            ...|.:..||:..|::::|..  ..|||:||...|..:..| |:||:.|.||.||:.|||....|
Human    67 LYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTL 131

  Fly   152 RQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDD 216
            |.|||     ||:.::.|:..|....:..|..:...|.|.:.::..|..|||||::...||...|
Human   132 RNFGM-----GKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKD 191

  Fly   217 PKFRRFNFLIEEGMRLFGE--IHTVDYIPT-MQCFPSISTAKNKIAQNRAEMQRFYQDVIDDHKR 278
            .:|......:.|.:|:...  |...:..|| :..||.   ..||:.:|.|.|:....:.:.:|:.
Human   192 QQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPG---THNKLLKNLAFMESDILEKVKEHQE 253

  Fly   279 SFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHE-----EQLVQVIIDLFSAGMETIKTTLL 338
            |.|.||.||.:|.:|.::||.|           :|.:     |.||....||..||.||..|||.
Human   254 SMDINNPRDFIDCFLIKMEKEK-----------QNQQSEFTIENLVITAADLLGAGTETTSTTLR 307

  Fly   339 WINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTR 403
            :..:.:|::|:...:||:|:::|:||:|.|.::|..::|.|::.:.|..|...::|.:..|:.|.
Human   308 YALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTC 372

  Fly   404 DVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLG 468
            ||:...|.||.|:.::..:.||..|...:..||.|.|..|:|..|..:|..||:||..|:|:|:|
Human   373 DVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVG 437

  Fly   469 DVLARMELFLFFASFMHCFDI-ALPEGQPLPSLKGNVGATITPESFKVC 516
            :.|||||||||....:..|:: :|.:.:.|.:.....|....|..:::|
Human   438 EGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLC 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	155/476 (33%)
CYP2C19	NP_000760.1	p450	30..487	CDD:365848	155/476 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm41747
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820