DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and CYP2B6

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_000758.1	Gene:	CYP2B6 / 1555	HGNCID:	2615	Length:	491	Species:	Homo sapiens

Alignment Length:	482	Identity:	160/482 - (33%)
Similarity:	249/482 - (51%)	Gaps:	38/482 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LMVFLGLLALVTLLQWLVRNYRELR-KLPPGPWGLPVIGYLLFMGSEKHTR-FMELAKQYGSLFS 89
            |.|.|.|..|..||..||:.:.... :|||||..||::|.||.|......: |:...::||.:|:
Human     3 LSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFT 67

  Fly    90 TRLGSQLTVVMSDYKMIRECF--RREEFTGRPD----TPFMQTLNGYGIINSTGKLWKDQRRFLH 148
            ..||.:..|::...:.|||..  :.|.|:||..    .||.:   |||:|.:.|..||..|||..
Human    68 VHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFR---GYGVIFANGNRWKVLRRFSV 129

  Fly   149 DKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFS 213
            ..:|.|||     ||:.:::||..|....|..|..|.|..:|.:.:.....:|:|||::...||.
Human   130 TTMRDFGM-----GKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFH 189

  Fly   214 IDDPKFRRFNFLIEEGMRL----FGEIHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVID 274
            ..|.:|.:...|..:...|    ||::..: :...::.||.   |..::.:|..|:..:....::
Human   190 YQDQEFLKMLNLFYQTFSLISSVFGQLFEL-FSGFLKYFPG---AHRQVYKNLQEINAYIGHSVE 250

  Fly   275 DHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVI----IDLFSAGMETIKT 335
            .|:.:.||:..:||:|.||..:||.|:..          |.|...|.:    :.||.||.||..|
Human   251 KHRETLDPSAPKDLIDTYLLHMEKEKSNA----------HSEFSHQNLNLNTLSLFFAGTETTST 305

  Fly   336 TLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHS 400
            ||.:..:.||:.|....||..|::||:|.||.|.:.|...:|.||:.|.|..|.|.::|:...|.
Human   306 TLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHI 370

  Fly   401 PTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRM 465
            .|:.....||.||..:.|..::::...||:.:|||:.|.|..|:|..|.::|.|.||||.:|:|:
Human   371 VTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRI 435

  Fly   466 CLGDVLARMELFLFFASFMHCFDIALP 492
            |||:.:||.||||||.:.:..|.:|.|
Human   436 CLGEGIARAELFLFFTTILQNFSMASP 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	150/454 (33%)
CYP2B6	NP_000758.1	p450	42..488	CDD:278495	143/443 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm41747
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.720