Protein Alignment Cyp18a1 and CYP2A13

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_000757.2
• Gene: CYP2A13 / 1553
• HGNCID: 2608
• Length: 494
• Species: Homo sapiens
• Alignment Length: 506
• Identity: 159/506 - (31%)
• Similarity: 264/506 - (52%)
• Gaps: 43/506 - (8%)

  Fly    26 LLMVFLGLLALVTLLQ-WLVRNYRELRKLPPGPWGLPVIGYLLFMGSEK-HTRFMELAKQYGSLF 88
            ||:..|..|.::.|:. |..|..|  .||||||..||.||..|.:.:|: :...|:::::||.:|
Human     7 LLVTLLACLTVMVLMSVWRQRKSR--GKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVF 69

  Fly    89 STRLGSQLTVVMSDYKMIRECF--RREEFTGRPD-TPFMQTLNGYGIINSTGKLWKDQRRFLHDK 150
            :..||.:..||:..:..::|..  :.|||:||.: ..|.....|||:..|.|:..|..|||....
Human    70 TIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLRRFSIAT 134

  Fly   151 LRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSID 215
            ||.||:     ||:.:::||..|....|..|..:.|..:|.:..:|..|||||.|::...||..:
Human   135 LRGFGV-----GKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYE 194

  Fly   216 DPKF--------RRFNFLIEEGMRLFGEIHTV-DYI--PTMQCFPSISTAKNKIAQNRAEMQRFY 269
            |.:|        ..|.|......:|:....:| .::  |..|.|..:...::.||:.
Human   195 DKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKK-------- 251

  Fly   270 QDVIDDHKRSFDPNNIRDLVDFYLCEI-EKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETI 333
               ::.::|:.|||:.||.:|.:|..: |:.|...|:..|   ||    ||...::||.||.||:
Human   252 ---VEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYL---KN----LVMTTLNLFFAGTETV 306

  Fly   334 KTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATT 398
            .|||.:..:.::::|:...:|.:|:|:|:|::|.|..||...:|.||:.|.|..|...::|:...
Human   307 STTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLA 371

  Fly   399 HSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGR 463
            |...:|.:...:.:|.|:.|.|::.||..||..:..|.:|.|..|:|.:|:.:|.:.|:||.:|:
Human   372 HRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGK 436

  Fly   464 RMCLGDVLARMELFLFFASFMHCFDIALPEG-QPLPSLKGNVGATITPESF 513
            |.|.|:.||||||||||.:.|..|....|:. :.:.....:||....|.::
Human   437 RYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNY 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	137/445 (31%)
CYP2A13	NP_000757.2	CYP2A	65..489	CDD:410761	138/446 (31%)