Protein Alignment Cyp18a1 and CYP2A7

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: XP_054175989.1
• Gene: CYP2A7 / 1549
• HGNCID: 2611
• Length: 572
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 141/551 - (25%)
• Similarity: 244/551 - (44%)
• Gaps: 107/551 - (19%)

  Fly    26 LLMVFLGLLALVTLLQ-WLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKH--TRFMELAKQYGSL 87
            ||:..|..|.::.|:. |..|..|  .||||||..||.||..|.:.:| |  ...|:::::||.:
Human     7 LLVALLACLTVMVLMSVWQQRKSR--GKLPPGPTPLPFIGNYLQLNTE-HICDSIMKISERYGPV 68

  Fly    88 FSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPD-TPFMQTLNGYGIINSTGKLWKDQRRFLHD 149
            |:..||.:..||:..:..:||..  :.|||:||.: ..|.....|||::.|.|:..|..|||...
Human    69 FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIA 133

  Fly   150 KLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSI 214
            .||.||:     ||:.:::||..|....|..:.::.|..::.:..:|..|||||.|::...||..
Human   134 TLRDFGV-----GKRGIEERIQEEAGFLIEAIRSTHGANIEPTFFLSRTVSNVISSIVFGDRFDY 193

  Fly   215 DDPKFRRFNFLIEEGMRLF-------GEIHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDV 272
            :|   :.|..|:...:.:|       |:::.: :...|:..|.......|:.|.   ::.|....
Human   194 ED---KEFLSLLSMMLGIFQFTSTSTGQLYEM-FSSVMKHLPGPQQQAFKLLQG---LEDFIAKK 251

  Fly   273 IDDHKRSFDPNNIRDLVDFYLCEI-EKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTT 336
            ::.::|:.|||:.:|.:|.:|..: |:.|...|:..|   ||    |:...::||.||.||:.||
Human   252 VEHNQRTLDPNSPQDFIDSFLIRMQEEEKNPNTEFYL---KN----LMMTTLNLFIAGTETVSTT 309

  Fly   337 LLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSP 401
            |.:..:.::::|:...:|.:|:|:|:|::|.|..||...:|..|:.|.|..|...::|::.....
Human   310 LCYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRV 374

  Fly   402 TRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMC 466
            .:|.:...:.:|          .|...|     |...|                    |:...:|
Human   375 KKDTKFRDFFLP----------KVLSSP-----PPRLR--------------------GLPALLC 404

  Fly   467 LGDVLARMELFLFFASFMHC----------------FDIALPEGQPLPSLKGNVGATITPESFKV 515
            :..:|..:|.|.   |..|.                |.:..||....|........|..|: ..:
Human   405 VPRILPPLEAFY---SLSHSLNQSKRTSPTTTSIPPFHLDTPESCISPDSLCRENQTQVPK-LPI 465

  Fly   516 CLKRRPL------------GPTAADPHHMRN 534
            ...|.||            ||    |:::|:
Human   466 LRNRSPLSIRPFVLGTQISGP----PNNLRS 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	111/456 (24%)
CYP2A7	XP_054175989.1	cytochrome_P450	65..>387	CDD:477761	95/350 (27%)