Protein Alignment Cyp18a1 and CYP2A6

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_000753.3
• Gene: CYP2A6 / 1548
• HGNCID: 2610
• Length: 494
• Species: Homo sapiens
• Alignment Length: 475
• Identity: 150/475 - (31%)
• Similarity: 257/475 - (54%)
• Gaps: 34/475 - (7%)

  Fly    26 LLMVFLGLLALVTLLQ-WLVRNYRELRKLPPGPWGLPVIGYLLFMGSEK-HTRFMELAKQYGSLF 88
            ||:..|..|.::.|:. |..|  :...||||||..||.||..|.:.:|: :...|:::::||.:|
Human     7 LLVALLVCLTVMVLMSVWQQR--KSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVF 69

  Fly    89 STRLGSQLTVVMSDYKMIRECF--RREEFTGRPD-TPFMQTLNGYGIINSTGKLWKDQRRFLHDK 150
            :..||.:..||:..:..:||..  :.|||:||.: ..|.....|||::.|.|:..|..|||....
Human    70 TIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIAT 134

  Fly   151 LRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSID 215
            ||.||:     ||:.:::||..|....|..|..:.|..:|.:..:|..|||||.|::...||
Human   135 LRDFGV-----GKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRF--- 191

  Fly   216 DPKFRRFNFLIEEGMRLF-------GEIHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVI 273
            |.|.:.|..|:...:.:|       |:::.: :...|:..|.......::.|.   ::.|....:
Human   192 DYKDKEFLSLLRMMLGIFQFTSTSTGQLYEM-FSSVMKHLPGPQQQAFQLLQG---LEDFIAKKV 252

  Fly   274 DDHKRSFDPNNIRDLVDFYLCEI-EKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTL 337
            :.::|:.|||:.||.:|.:|..: |:.|...|:..|   ||    ||...::||..|.||:.|||
Human   253 EHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYL---KN----LVMTTLNLFIGGTETVSTTL 310

  Fly   338 LWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPT 402
            .:..:.::::|:...:|.:|:|:|:|::|.|..||...:|..|:.|.|..|...::|::......
Human   311 RYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVK 375

  Fly   403 RDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCL 467
            :|.:...:.:|.|:.|.|::.||..||:.:..|::|.|..|::.:|:.:|.:.|:||.:|:|.|.
Human   376 KDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCF 440

  Fly   468 GDVLARMELFLFFASFMHCF 487
            |:.||||||||||.:.|..|
Human   441 GEGLARMELFLFFTTVMQNF 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	129/414 (31%)
CYP2A6	NP_000753.3	CYP2A	65..489	CDD:410761	130/415 (31%)