DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and CYP1B1

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_000095.2	Gene:	CYP1B1 / 1545	HGNCID:	2597	Length:	543	Species:	Homo sapiens

Alignment Length:	518	Identity:	176/518 - (33%)
Similarity:	261/518 - (50%)	Gaps:	26/518 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LRQLQVQQDGDAQHLLMVFLGLLALVTLLQWLVR-NYRELRKLPPGPWGLPVIGYLLFMGSEKHT 75
            |..|.:||.     .|::.|.:||.|.:.|.|:| ..|:||..||||:..|:||....:|...|.
Human    13 LNPLSIQQT-----TLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVGQAAHL 72

  Fly    76 RFMELAKQYGSLFSTRLGSQLTVVMSDYKMIRECFRRE--EFTGRPDTPFMQTLNG-----YGII 133
            .|..||::||.:|..||||...||::..:.|.:...::  .|..||.....:.::|     :|
Human    73 SFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFG-- 135

  Fly   134 NSTGKLWKDQRRFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHL--HASDGQPVDMSPVIS 196
             ...:.||.|||..|..:|.| .|.....:|.::..:::|..|.:..|  .::||..:|..|:..
Human   136 -HYSEHWKVQRRAAHSMMRNF-FTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTV 198

  Fly   197 VAVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPS-ISTAKNKIAQ 260
            |||:||:.::....|:|.|||:||......||..|..|....||.:|.:|.||: :.|...:..|
Human   199 VAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQ 263

  Fly   261 NRAEMQRFYQDVIDDHKRSFDPNNI-RDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIID 324
            .......|..|....|..|..|... ||::|.::...|| ||.| |:.....:...|.:...|.|
Human   264 LNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEK-KAAG-DSHGGGARLDLENVPATITD 326

  Fly   325 LFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRR 389
            :|.|..:|:.|.|.|:.:...|.|....|||.||||||||.|||.:.|...||...:.:.|:||.
Human   327 IFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRF 391

  Fly   390 SSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRK-- 452
            ||.||:...|:.|.:..:.||.||..:.|.....||:.||..|..||.|.|:||:|.:|.:.|
Human   392 SSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDL 456

  Fly   453 PEYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKV 515
            ....:.|.||:|.|:|:.|::|:||||.:...|..|......:| ..:..:.|.||.|:||||
Human   457 TSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEP-AKMNFSYGLTIKPKSFKV 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	161/475 (34%)
CYP1B1	NP_000095.2	p450	51..520	CDD:365848	161/475 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920