Protein Alignment Cyp18a1 and CYP1B1

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_000095.2
• Gene: CYP1B1 / 1545
• HGNCID: 2597
• Length: 543
• Species: Homo sapiens
• Alignment Length: 518
• Identity: 176/518 - (33%)
• Similarity: 261/518 - (50%)
• Gaps: 26/518 - (5%)

  Fly    12 LRQLQVQQDGDAQHLLMVFLGLLALVTLLQWLVR-NYRELRKLPPGPWGLPVIGYLLFMGSEKHT 75
            |..|.:||.     .|::.|.:||.|.:.|.|:| ..|:||..||||:..|:||....:|...|.
Human    13 LNPLSIQQT-----TLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVGQAAHL 72

  Fly    76 RFMELAKQYGSLFSTRLGSQLTVVMSDYKMIRECFRRE--EFTGRPDTPFMQTLNG-----YGII 133
            .|..||::||.:|..||||...||::..:.|.:...::  .|..||.....:.::|     :|
Human    73 SFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFG-- 135

  Fly   134 NSTGKLWKDQRRFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHL--HASDGQPVDMSPVIS 196
             ...:.||.|||..|..:|.| .|.....:|.::..:::|..|.:..|  .::||..:|..|:..
Human   136 -HYSEHWKVQRRAAHSMMRNF-FTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTV 198

  Fly   197 VAVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPS-ISTAKNKIAQ 260
            |||:||:.::....|:|.|||:||......||..|..|....||.:|.:|.||: :.|...:..|
Human   199 VAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQ 263

  Fly   261 NRAEMQRFYQDVIDDHKRSFDPNNI-RDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIID 324
            .......|..|....|..|..|... ||::|.::...|| ||.| |:.....:...|.:...|.|
Human   264 LNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEK-KAAG-DSHGGGARLDLENVPATITD 326

  Fly   325 LFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRR 389
            :|.|..:|:.|.|.|:.:...|.|....|||.||||||||.|||.:.|...||...:.:.|:||.
Human   327 IFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRF 391

  Fly   390 SSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRK-- 452
            ||.||:...|:.|.:..:.||.||..:.|.....||:.||..|..||.|.|:||:|.:|.:.|
Human   392 SSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDL 456

  Fly   453 PEYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKV 515
            ....:.|.||:|.|:|:.|::|:||||.:...|..|......:| ..:..:.|.||.|:||||
Human   457 TSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEP-AKMNFSYGLTIKPKSFKV 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	146/442 (33%)
CYP1B1	NP_000095.2	CYP1B1-like	81..518	CDD:410768	147/443 (33%)