DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2j6

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_034138.3	Gene:	Cyp2j6 / 13110	MGIID:	1270148	Length:	501	Species:	Mus musculus

Alignment Length:	500	Identity:	166/500 - (33%)
Similarity:	268/500 - (53%)	Gaps:	41/500 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LLALVTLLQWLVRNY---RELRKLPPGPWGLPVIGYLLFMG-SEKHTRFMELAKQYGSLFSTRLG 93
            |:|.||.|  |:.:|   |..:..||||||||.:|.:..:. .:.|.....|.|:||::||..||
Mouse    22 LVAAVTFL--LLADYFKNRRPKNYPPGPWGLPFVGNIFQLDFGQPHLSIQPLVKKYGNIFSLNLG 84

  Fly    94 SQLTVVMSDYKMIRECFRREE--FTGRPDTPFMQTL-NGYGIINSTGKLWKDQRRFLHDKLRQFG 155
            ...:||::...:|:|...:.|  ...||.:...:.: |..|:|.|:|::||:||||....||.||
Mouse    85 DITSVVITGLPLIKEALTQMEQNIMNRPLSVMQERISNKNGLIFSSGQIWKEQRRFALMTLRNFG 149

  Fly   156 MTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKFR 220
            :     ||:.:::|:..|....:..:...:|:|.:....|:.||||:|||:....||...|.:|:
Mouse   150 L-----GKKSLEERMQEEASHLVEAIREEEGKPFNPHFSINNAVSNIICSVTFGERFDYHDSRFQ 209

  Fly   221 RFNFLIEEGMRL----FGEIHTV-----DYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDH 276
            ....|::|.|.|    ..:::.:     .|||         .:..|:.:|..:::.|...:||||
Mouse   210 EMLRLLDEVMYLETTMISQLYNIFPWIMKYIP---------GSHQKVFRNWEKLKLFVSCMIDDH 265

  Fly   277 KRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWIN 341
            ::.::|:..||.:|.:|.|:.|...:.|..       :||.|:...:|||.||.||..|||.|..
Mouse   266 RKDWNPDEPRDFIDAFLKEMTKYPEKTTSF-------NEENLICSTLDLFFAGTETTSTTLRWAL 323

  Fly   342 VFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVE 406
            ::|...|:...:||.|:|:|:|:.|...:.|.:.:|.|.:.|.|..|..:|:||........|..
Mouse   324 LYMALYPEVQEKVQAEIDRVIGQKRAARLADRESMPYTNAVIHEVQRMGNIIPLNVPREVAMDTN 388

  Fly   407 LNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVL 471
            |||:.:|.|:.|:..:.::|.||..|..|:.|.|..|:: .|:.:|.|.|:||.:|:|.|||:.|
Mouse   389 LNGFHLPKGTMVLTNLTALHRDPKEWATPDVFNPEHFLE-NGQFKKRESFLPFSMGKRACLGEQL 452

  Fly   472 ARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVC 516
            ||.|||:||.|.|..|....|..:.| |.|...|.|::|.|.::|
Mouse   453 ARSELFIFFTSLMQKFTFNPPINEKL-SPKFRNGLTLSPVSHRIC 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	157/475 (33%)
Cyp2j6	NP_034138.3	p450	44..496	CDD:278495	157/474 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	290	1.000	Domainoid score	I1539
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	302	1.000	Inparanoid score	I2648
Isobase	1	0.950	-	0	Normalized mean entropy	S3462
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm43796
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.720