DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2g1

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_038837.1	Gene:	Cyp2g1 / 13108	MGIID:	109612	Length:	494	Species:	Mus musculus

Alignment Length:	516	Identity:	168/516 - (32%)
Similarity:	278/516 - (53%)	Gaps:	41/516 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GDAQHLLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSE-KHTRFMELAKQY 84
            |.|..:.|. |.|..|:.|:.|  :...:..||||||..:|.:|..|.:.:: ....|.:|.|:|
Mouse     4 GGAFSIFMA-LCLSCLLILIAW--KRTSKGGKLPPGPTPIPFLGNFLQVRTDATFQSFQKLQKKY 65

  Fly    85 GSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQ-TLNGYGIINSTGKLWKDQRRF 146
            ||:|:...|.:..||:..::.::|..  :.::|:||.:.|.:: ...|||:..|.|:.||..|||
Mouse    66 GSVFTVYFGPRPVVVLCGHEAVKEALVDQADDFSGRGEMPTLEKNFQGYGLALSNGERWKILRRF 130

  Fly   147 LHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTR 211
            ....||.|||     ||:.:::||..|....:..||...|.|:|.:..:|..|||||||::...|
Mouse   131 SLTVLRNFGM-----GKRSIEERIQEEAGYLLEELHKVKGAPIDPTLYLSRTVSNVICSVVFGKR 190

  Fly   212 FSIDDPKFRRFNFLIEEGM----RLFGEIHTVDYIPTMQCFPSISTAKNKIAQNRAE-MQRFYQD 271
            |...|.:|:....:|.|..    :.:.:::.: |...||.||    .::....|..| ::.|...
Mouse   191 FDYQDQRFQSLMRMINESFVEMSKPWAQLYDM-YWKVMQYFP----GRHNYLYNLIEDLKDFIAS 250

  Fly   272 VIDDHKRSFDPNNIRDLVDFYLCEIEKAKAE-GTDAELFDGKNHEEQLVQVIIDLFSAGMETIKT 335
            .:..::.||||:|.||.:|.:|.::.:.|:: .|:   |:.||    ||...::||.||.||:.:
Mouse   251 RVKINEASFDPSNPRDFIDCFLIKMHQDKSDPHTE---FNLKN----LVLTTLNLFFAGTETVSS 308

  Fly   336 TLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHS 400
            ||.:..:.:|:.|:...::.:|::||:|.||.|.::|...:|.|::.|.|..|.:.||||...|:
Mouse   309 TLRYGFLLLLKYPEVEAKIHEEINQVIGTHRTPRVDDRAKMPYTDAVIHEIQRLTDIVPLGVPHN 373

  Fly   401 PTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRM 465
            .|||....||.:|.|:.|.||..||..||..:..|:.|.|..|:|.:|:.:|.:.|:.|..|:|:
Mouse   374 VTRDTHFRGYLLPKGTDVYPLFGSVLKDPKYFRYPDAFYPQHFLDEQGRFKKNDAFVVFSSGKRI 438

  Fly   466 CLGDVLARMELFLFFASFMHCFDI--ALPEGQPLPSLK----GNVGATITPESFKVCLKRR 520
            |:|:.||||||||:|.|.:..|.:  .:|......:.|    ||:     |..:::|...|
Mouse   439 CVGEALARMELFLYFTSILQRFSLRSLVPPADIDIAHKISGFGNI-----PPVYELCFMAR 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	156/478 (33%)
Cyp2g1	NP_038837.1	p450	34..491	CDD:278495	156/478 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm43796
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720