DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2f2

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_031843.2	Gene:	Cyp2f2 / 13107	MGIID:	88608	Length:	491	Species:	Mus musculus

Alignment Length:	527	Identity:	179/527 - (33%)
Similarity:	285/527 - (54%)	Gaps:	63/527 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DGDAQHLLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEK-HTRFMELAKQ 83
            ||.:..:|::.|.:::|.     |..:.|...:|||||..||::|.||.:.|:. .|...:|:|:
Mouse     2 DGVSTAILLLLLAVISLS-----LTFSSRGKGQLPPGPKPLPILGNLLQLRSQDLLTSLTKLSKE 61

  Fly    84 YGSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTP-FMQTLNGYGIINSTGKLWKDQRR 145
            |||:|:..|||:..:|:|.|:.::|..  :.|||:||...| |.....|.||..|.|:.||..||
Mouse    62 YGSVFTVYLGSRPVIVLSGYQTVKEALVDKGEEFSGRGAYPVFFNFTRGNGIAFSDGERWKILRR 126

  Fly   146 FLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMST 210
            |....||.|||     ||:.:::||:.|....:..|...:|:|.|...::|.:|||:|||::..:
Mouse   127 FSVQILRNFGM-----GKRSIEERILEEGSFLLEVLRKMEGKPFDPVFILSRSVSNIICSVVFGS 186

  Fly   211 RFSIDDPKFRRFNFLIEEGMRL----FGEIHTV-----DYI--PTMQCFPSISTAKNKIAQNRAE 264
            ||..||.:.......|.:..::    :||::.:     |:|  |..:.|.:....|:.||::
Mouse   187 RFDYDDERLLTIIHFINDNFKIMSSPWGEMYNIFPSVLDWIPGPHKRLFRNFGGMKDLIARS--- 248

  Fly   265 MQRFYQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNH--EEQLVQVIIDLFS 327
                    :.:|:.|.|||:.||.:|.:|.::.:.|.        |..:|  .:.|:....:|..
Mouse   249 --------VREHQDSLDPNSPRDFIDCFLTKMAQEKQ--------DPLSHFNMDTLLMTTHNLLF 297

  Fly   328 AGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSI 392
            .|.||:.|||....:.:::.||...|||:|:|:||||.|:||:||...:|.|::.|.|..|.:.:
Mouse   298 GGTETVGTTLRHAFLILMKYPKVQARVQEEIDRVVGRSRMPTLEDRTSMPYTDAVIHEVQRFADV 362

  Fly   393 VPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFI 457
            :|:...|..|||....|:.||.|:.||.|:|:||.|.:.::.|:||.|..|:|.....:|...|:
Mouse   363 IPMNLPHRVTRDTPFRGFLIPKGTDVITLLNTVHYDSDQFKTPQEFNPEHFLDDNHSFKKSPAFM 427

  Fly   458 PFGVGRRMCLGDVLARMELFLFFASFMHCF---------DIALPEGQPLPSLKGNVGATITPESF 513
            ||..|||:|||:.|||||||::|.|.:..|         ||.|   .||.|..||:     |..|
Mouse   428 PFSAGRRLCLGEPLARMELFIYFTSILQNFTLQPLVDPEDIDL---TPLSSGLGNL-----PRPF 484

  Fly   514 KVCLKRR 520
            ::|:..|
Mouse   485 QLCMHIR 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	169/488 (35%)
Cyp2f2	NP_031843.2	p450	31..488	CDD:278495	169/488 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm43796
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820