Protein Alignment Cyp18a1 and Cyp2c40

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_034134.3
• Gene: Cyp2c40 / 13099
• MGIID: 1306815
• Length: 491
• Species: Mus musculus
• Alignment Length: 509
• Identity: 155/509 - (30%)
• Similarity: 250/509 - (49%)
• Gaps: 46/509 - (9%)

  Fly    26 LLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIG-YLLFMGSEKHTRFMELAKQYGSLFS 89
            :|::.|..|.:::|  |..|:.|  ..|||||..||:|| |.|....:........:|.||.:|:
Mouse     6 VLVLCLSFLLVLSL--WRQRSAR--GNLPPGPTPLPIIGNYHLIDMKDIGQCLTNFSKTYGPVFT 66

  Fly    90 TRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTP-FMQTLNGYGIINSTGKLWKDQRRFLHDKL 151
            ...|||..||:..|:.|:|..  ..|||:||...| |.:...|.||..|.|.:||..|.|..:.|
Mouse    67 LYFGSQPIVVLHGYEAIKEALIDHGEEFSGRGRIPVFDKVSTGKGIGFSHGNVWKATRVFTVNTL 131

  Fly   152 RQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDD 216
            |..||     ||:.::.::..|....:..|..::|.|.|...:|..|..|||||::...||...|
Mouse   132 RNLGM-----GKRTIENKVQEEAQWLMKELKKTNGSPCDPQFIIGCAPCNVICSIVFQNRFDYKD 191

  Fly   217 PKFRRF--------NFLIEEGMRLFGEIH-TVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDV 272
            ..|...        ..|...|.::|..:. .:||.|         .:.||:.:|...::.:....
Mouse   192 KDFLSLIGKVNECTEILSSPGCQIFNAVPILIDYCP---------GSHNKLFKNHTWIKSYLLGK 247

  Fly   273 IDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHE----EQLVQVIIDLFSAGMETI 333
            |.:|:.|.|..|.||.:|::|  |::.:..|.:        |.    |.|..::.||...|.||:
Mouse   248 IKEHEESLDVTNPRDFIDYFL--IQRRQKNGIE--------HMDYTIEHLATLVTDLVFGGTETL 302

  Fly   334 KTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATT 398
            .:|:.:..:.::::.....:||:|:|.|:||||.|.::|..::|.|.:.:.|..|...:.|....
Mouse   303 SSTMRFALLLLMKHTHITAKVQEEIDNVIGRHRSPCMQDRNHMPYTNAMVHEVQRYIDLGPNGVV 367

  Fly   399 HSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGR 463
            |..|.|.:...|.||.|:.|:..:.||..|...:..||.|.|..|:|..|..:|.:||:||..|:
Mouse   368 HEVTCDTKFRNYFIPKGTQVMTSLTSVLHDSTEFPNPEVFDPGHFLDDNGNFKKSDYFVPFSAGK 432

  Fly   464 RMCLGDVLARMELFLFFASFMHCFDI-ALPEGQPLPSLKGNVGATITPESFKVC 516
            |:|:|:.|||||||||..:.:..|.: .|.:.:.:.....:.|.:..|.:|::|
Mouse   433 RICVGESLARMELFLFLTTILQNFKLKPLVDPKDIDMTPKHSGFSKIPPNFQMC 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	134/446 (30%)
Cyp2c40	NP_034134.3	CYP2C-like	61..485	CDD:410758	135/447 (30%)